Creatine supplementation for weak muscles in persons with chronic tetraplegia: a randomized double-blind placebo-controlled crossover trial
Kendall RW, Jacquemin G, Frost R, Burns SP
The journal of spinal cord medicine · 12 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-01-01 · J Spinal Cord Med · vol. 28 · número 3 · págs. 208–213
- Editorial
- Taylor & Francis
- Citado
- 18 citas · más que el 62% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Spinal Cord Injury Research · Muscle Physiology and Disorders
- Palabras clave
- creatine supplementation, tetraplegia, muscle strength, muscular endurance, hand function, spinal cord injury
- MeSH
- hand, wrist, muscle, skeletal, cervical vertebrae, humans, muscle weakness, spinal cord injuries, quadriplegia, chronic disease, creatine, hand strength, treatment failure, cross-over studies, double-blind method, physical endurance, isometric contraction, middle aged, female, male
4 autores
- Richard W. Kendall🇺🇸University of Utah
- Geraldine J. Jacquemin🇨🇦Université de Montréal
- Randee Frost🇺🇸VA Puget Sound Health Care System
- Stephen P. Burns🇺🇸 · autor de correspondenciaUniversity of Washington; VA Puget Sound Health Care System; Harborview Injury Prevention and Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Creatine supplementation improves muscle strength in some patient populations with neurologic disorders. The purpose of this study was to determine whether creatine supplementation improves muscle strength and endurance in weak upper limb muscles in persons with tetraplegia, and whether it improves function.
Methods
Outpatients with tetraplegia and mild wrist extensor weakness were randomized to receive either creatine or placebo in a double-blind crossover design. During creatine supplementation, participants were loaded with 10 g orally twice per day for 6 days, then maintained on 5 g daily until undergoing testing. Main outcome measures, performed at baseline, after placebo, and after creatine supplementation, included maximal voluntary wrist extensor isometric contraction strength (MVC), endurance times for 5 submaximal wrist extensor contractions, and the Grasp and Release Test for hand function.
Results
Eight individuals (7 men, 1 woman) with tetraplegia met inclusion criteria and completed all study phases. The mean age of participants was 48 years, and 7 of 8 had C6 motor level injuries. There were no significant differences in MVC, endurance times, or hand function for creatine vs placebo.
Conclusion
Creatine does not improve MVC and endurance of weak wrist extensors and does not improve hand function in individuals with tetraplegia.
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