Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents
Abrams SA, Griffin IJ, Hawthorne KM, Gunn SK, Gundberg CM, Carpenter TO
The Journal of clinical endocrinology and metabolism · 110 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Texas Children's Hospital
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NCRR NIH HHS
- Gobierno
- NICHD NIH HHS
- Gobierno
- NIAMS NIH HHS
- Subvenciones
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR043740); National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR43740); National Center for Research Resources (RR 00188); National Center for Research Resources (K01 RR000188); National Center for Research Resources (M01RR000188); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-K24-01288)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2005-10-01 · J Clin Endocrinol Metab · vol. 90 · número 10 · págs. 5576–5581
- Editorial
- Oxford University Press
- Citado
- 174 citas · más que el 96% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D status, parathyroid hormone, calcium absorption, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, adolescents, prepubertal children, osteocalcin, bone mineral density, vitamin D insufficiency, bone formation
- MeSH
- humans, calcium, 25-hydroxyvitamin d 2, parathyroid hormone, vitamin d, osteocalcin, endpoint determination, diet, puberty, bone density, genotype, dietary supplements, adolescent, child, female, male
6 autores
- Steven A. Abrams🇺🇸 · autor de correspondenciaAgricultural Research Service; United States Department of Agriculture; Children's Nutrition Research Center at Baylor College of Medicine
- Ian J. Griffin🇺🇸Agricultural Research Service; United States Department of Agriculture; Children's Nutrition Research Center at Baylor College of Medicine
- Keli M. Hawthorne🇺🇸Agricultural Research Service; United States Department of Agriculture; Children's Nutrition Research Center at Baylor College of Medicine
- Sheila Gunn🇺🇸Baylor College of Medicine; Texas Children's Hospital
- Caren M. Gundberg🇺🇸Yale University
- Thomas O. Carpenter
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Evidence suggests that vitamin D status in adults, as assessed by serum 25-hydroxyvitamin D (25-OHD), is positively associated with calcium absorption fraction and inversely associated with serum PTH. Few comparable pediatric data exist.
Objectives
The objective of this study was to evaluate the relationships among vitamin D status, PTH, and calcium absorption in midpubertal boys and girls.
Methods
Calcium absorption was measured as part of an evaluation of the effects of prebiotics (inulin-type fructans) using a stable isotope method in 93 young adolescents, 12.7 +/- 1.0 yr of age, receiving diets averaging approximately 900 mg/d calcium.
Results
A significant positive relation to calcium absorption was found for serum 1,25-dihydroxyvitamin D (P = 0.048) and PTH (P = 0.007), but not for 25-OHD (P = 0.77). PTH was significantly inversely related to 25-OHD and was positively related to serum 1,25-dihydroxyvitamin D and osteocalcin. PTH was marginally significantly inversely related to lumbar spinal, but not whole body, bone mineral density.
Conclusions
These data suggest that in adolescents, especially in the presence of vitamin D insufficiency, PTH secretion increases to adapt to higher rates of bone formation associated with growth. This results in higher serum 1,25(OH)2D concentrations and increased calcium absorption results. Vitamin D status, as reflected by the serum 25-OHD level, is not closely related to calcium absorption. Whether adaptation to low serum 25-OHD is adequate under physiologically stressful situations, including those leading to very low serum 25-OHD levels, is unknown.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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