Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation
Westerterp-Plantenga MS, Lejeune MP, Kovacs EM
Obesity research · 189 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-07-01 · Obes Res · vol. 13 · número 7 · págs. 1195–1204
- Editorial
- Wiley
- Citado
- 328 citas · más que el 99% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Tea Polyphenols and Effects · Coffee research and impacts · Regulation of Appetite and Obesity
- Palabras clave
- weight loss, weight maintenance, green tea, caffeine, epigallocatechin gallate, obesity, overweight, very low calorie diet, leptin, satiety, resting energy expenditure, respiratory quotient, fat oxidation, thermogenesis, waist circumference, fat mass
- MeSH
- adipose tissue, humans, obesity, weight loss, caffeine, leptin, basal metabolism, diet, reducing, double-blind method, feeding behavior, satiation, energy metabolism, oxidation-reduction, oxygen consumption, thermogenesis, tea, adolescent, adult, middle aged, female, male
3 autores
- Margriet S. Westerterp‐Plantenga🇳🇱 · autor de correspondenciaMaastricht University
- Manuela P. G. M. Lejeune🇳🇱Maastricht University
- Eva M. R. Kovacs🇳🇱Maastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Investigation of the effect of a green tea-caffeine mixture on weight maintenance after body weight loss in moderately obese subjects in relation to habitual caffeine intake.
Research methods and procedures
A randomized placebo-controlled double blind parallel trial in 76 overweight and moderately obese subjects, (BMI, 27.5 +/- 2.7 kg/m2) matched for sex, age, BMI, height, body mass, and habitual caffeine intake was conducted. A very low energy diet intervention during 4 weeks was followed by 3 months of weight maintenance (WM); during the WM period, the subjects received a green tea-caffeine mixture (270 mg epigallocatechin gallate + 150 mg caffeine per day) or placebo.
Results
Subjects lost 5.9 +/-1.8 (SD) kg (7.0 +/- 2.1%) of body weight (p < 0.001). At baseline, satiety was positively, and in women, leptin was inversely, related to subjects' habitual caffeine consumption (p < 0.01). High caffeine consumers reduced weight, fat mass, and waist circumference more than low caffeine consumers; resting energy expenditure was reduced less and respiratory quotient was reduced more during weight loss (p < 0.01). In the low caffeine consumers, during WM, green tea still reduced body weight, waist, respiratory quotient and body fat, whereas resting energy expenditure was increased compared with a restoration of these variables with placebo (p < 0.01). In the high caffeine consumers, no effects of the green tea-caffeine mixture were observed during WM.
Discussion
High caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women. In habitual low caffeine consumers, the green tea-caffeine mixture improved WM, partly through thermogenesis and fat oxidation.
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