Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study
Ellegård L, Andersson H, Bosaeus I
European journal of clinical nutrition · 17 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Göteborgs Läkaresällskap
- Universidad u hospital
- Sahlgrenska Universitetssjukhuset
- Organización sin fines de lucro
- Svenska Läkaresällskapet
Según 3 financiadores declarados.
Publicación
- Publicado
- 2005-08-10 · Eur J Clin Nutr · vol. 59 · número 12 · págs. 1374–1378
- Editorial
- Springer Nature
- Citado
- 36 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- rapeseed oil, olive oil, phytosterols, cholesterol metabolism, cholesterol absorption, ileostomy, bile acids, bile acid synthesis, serum cholesterol, lathosterol, 7α-hydroxy-4-cholesten-3-one, dietary fat
- MeSH
- humans, bile acids and salts, cholesterol, phytosterols, dietary fats, fatty acids, monounsaturated, plant oils, ileostomy, cross-over studies, intestinal absorption, dietary fiber, adult, aged, aged, 80 and over, middle aged, female, male, olive oil, rapeseed oil
3 autores
- Lars Ellegård🇸🇪 · autor de correspondenciaSahlgrenska University Hospital; University of Gothenburg
- Henrik A. Andersson🇸🇪Sahlgrenska University Hospital
- Ingvar G. Bosaeus🇸🇪Sahlgrenska University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To study whether olive oil and rapeseed oil have different effects on cholesterol metabolism.
Design
Short-term experimental study, with controlled diets.
Setting
Outpatients at a metabolic-ward kitchen.
Subjects
A total of nine volunteers with conventional ileostomies.
Interventions
Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil.
Main outcome measures
Cholesterol absorption, ileal excretion of cholesterol, and bile acids. Serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test.
Results
Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease cholesterol absorption by 11% (P = 0.050), and increased excretion of cholesterol, bile acids, and their sum as sterols by 9% (P = 0.021), 32% (P = 0.038), and 51% (P = 0.011) compared to olive oil. A serum marker for bile acid synthesis (7alpha-hydroxy-4-cholesten-3-one) increased by 28% (P = 0.038) within 10 h of consumption, and serum cholesterol levels decreased by 7% (P = 0.024), whereas a serum marker for cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged.
Conclusions
Rapeseed oil and olive oil have different effects on cholesterol metabolism. Rapeseed oil, tends to decrease cholesterol absorption, increases excretion of cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols.
Sponsorship
Supported by the Göteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Göteborg.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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