Clustering of haemostatic variables and the effect of high cashew and walnut diets on these variables in metabolic syndrome patients
Pieters M, Oosthuizen W, Jerling JC, Loots DT, Mukuddem-Petersen J, Hanekom SM
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 16 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-08-05 · Blood Coagul Fibrinolysis · vol. 16 · número 6 · págs. 429–437
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 24 citas · más que el 78% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Diabetes, Cardiovascular Risks, and Lipoproteins · Nutritional Studies and Diet
- Palabras clave
- metabolic syndrome, nut consumption, fibrinogen, factor VII coagulant activity, von Willebrand factor, plasminogen activator inhibitor-1, tissue plasminogen activator, thrombin-activatable fibrinolysis inhibitor, HDL cholesterol, obesity, weight loss, dietary intervention, endothelial function
- MeSH
- humans, anacardium, juglans, nuts, weight loss, blood coagulation factors, hemostasis, middle aged, female, male, cholesterol, hdl, metabolic syndrome
6 autores
- Marlien Pieters🇿🇦 · autor de correspondenciaNorth-West University; National Research Foundation
- Welma Stonehouse🇿🇦North-West University; National Research Foundation
- Johann C. Jerling🇿🇦North-West University; National Research Foundation
- Du Toit Loots🇿🇦North-West University; National Research Foundation
- Janine Mukuddem-Petersen🇿🇦North-West University; National Research Foundation
- Susanna Magrietha Hanekom🇿🇦North-West University; National Research Foundation
Resumen
El texto original del estudio, en el idioma en que se publicó.
We investigated the effect of a high walnut and cashew diet on haemostatic variables in people with the metabolic syndrome. Factor analysis was used to determine how the haemostatic variables cluster with other components of the metabolic syndrome and multiple regression to determine possible predictors. This randomized, control, parallel, controlled-feeding trial included 68 subjects who complied with the Third National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol criteria. After a 3-week run-in following the control diet, subjects were divided into three groups receiving either walnuts or cashews (20 energy%) or a control diet for 8 weeks. The nut intervention had no significant effect on von Willebrand factor antigen, fibrinogen, factor VII coagulant activity, plasminogen activator inhibitor 1 activity, tissue plasminogen activator activity or thrombin activatable fibrinolysis inhibitor. Statistically, fibrinogen clustered with the body-mass-correlates and acute phase response factors, and factor VII coagulant activity clustered with high-density lipoprotein cholesterol (HDL-C). Tissue plasminogen activator activity, plasminogen activator inhibitor 1 activity and von Willebrand factor antigen clustered into a separate endothelial function factor. HDL-C and markers of obesity were the strongest predictors of the haemostatic variables. We conclude that high walnut and cashew diets did not influence haemostatic factors in this group of metabolic syndrome subjects. The HDL-C increase and weight loss may be the main focus of dietary intervention for the metabolic syndrome. Furthermore, diet composition may have only limited effects if weight loss is not achieved.
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