Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients
Weinstock-Guttman B, Baier M, Park Y, Feichter J, Lee-Kwen P, Gallagher E, Venkatraman J, Meksawan K, Deinehert S, Pendergast D, Awad AB, Ramanathan M, Munschauer F, Rudick R
Prostaglandins, leukotrienes, and essential fatty acids · 137 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-08-16 · Prostaglandins Leukot Essent Fatty Acids · vol. 73 · número 5 · págs. 397–404
- Editorial
- Elsevier BV
- Citado
- 212 citas · más que el 92% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Multiple Sclerosis Research Studies · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- relapsing-remitting multiple sclerosis, omega-3 fatty acids, fish oil supplementation, low-fat diet, olive oil, dietary intervention, quality of life, physical function, fatigue, relapse rate, disease-modifying therapy
- MeSH
- humans, multiple sclerosis, relapsing-remitting, recurrence, fatty acids, omega-3, plant oils, treatment outcome, diet, fat-restricted, follow-up studies, double-blind method, time, dietary supplements, adolescent, adult, middle aged, female, male, olive oil
14 autores
- Bianca Weinstock‐Guttman🇺🇸 · autor de correspondenciaState University of New York; Jacobs Institute; Buffalo General Medical Center
- Monika L Baier🇺🇸University of Alabama at Birmingham
- Youngmin Park🇺🇸University at Buffalo, State University of New York
- Joan Feichter🇺🇸State University of New York; Jacobs Institute; Buffalo General Medical Center
- Peterkin Lee Kwen🇺🇸State University of New York; Jacobs Institute; Buffalo General Medical Center
- Eileen Gallagher🇺🇸State University of New York; Jacobs Institute; Buffalo General Medical Center
- Jaya T. Venkatraman🇺🇸University at Buffalo, State University of New York
- Kulwara Meksawan🇺🇸University at Buffalo, State University of New York
- Suzanne Deinehert🇺🇸Women & Children's Hospital of Buffalo
- David Pendergast🇷🇺Department of Biological Sciences
- Atif B. Awad🇺🇸University at Buffalo, State University of New York
- Murali Krishna Ramanathan🇺🇸State University of New York; University at Buffalo, State University of New York
- Frederick E. Munschauer🇺🇸State University of New York; Jacobs Institute; Buffalo General Medical Center
- Richard A. Rudick🇺🇸Cleveland Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine whether a low fat diet supplemented with omega-3 positively affects quality of life (QOL) in relapsing-remitting MS (RRMS) patients. In this 1-year long double-blind, randomized trial, patients were randomized to two dietary interventions: the "Fish Oil" (FO) group received a low fat diet (15% fat) with omega-3 FOs and the "Olive Oil" (OO) group received the AHA Step I diet (fat 30%) with OO supplements. The primary outcome measure was the Physical Components Summary Scale (PCS) of the Short Health Status Questionnaire (SF-36). Additional measures using MS specific QOL questionnaires, neurological status and relapse rate were obtained.
Results
31 RRMS patients were enrolled, with mean follow up over 11 +/- SD 2.9 months. Clinical benefits favoring the FO group were observed on PCS/SF-36 (P = 0.050) and MHI (P = 0.050) at 6 months. Reduced fatigue was seen on the OO diet at 6 months (P = 0.035). The relapse rate decreased in both groups relative to the rates during the 1 year preceding the study: mean change in relapse rate in the FO group: -0.79 +/- SD 1.12 relapses/year (P = 0.021) vs. -0.69 +/- SD 1.11 (P = 0.044) in the OO group. This study suggests that a low fat diet supplemented with omega-3 PUFA can have moderate benefits in RRMS patients on concurrent disease modifying therapies.
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