Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomised double-blind study of an olive oil-based lipid emulsion v. medium/long-chain triacylglycerols
García-de-Lorenzo A, Denia R, Atlan P, Martinez-Ratero S, Le Brun A, Evard D, Bereziat G
The British journal of nutrition · 50 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- European Society for Clinical Nutrition and Metabolism
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-08-01 · Br J Nutr · vol. 94 · número 2 · págs. 221–230
- Editorial
- Cambridge University Press
- Citado
- 80 citas · más que el 93% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Burn Injury Management and Outcomes · Central Venous Catheters and Hemodialysis
- Palabras clave
- total parenteral nutrition, lipid emulsions, medium-chain triglycerides, long-chain triglycerides, linoleic acid, severe burns, fatty acid metabolism, essential fatty acid deficiency, liver function tests, sepsis, interleukin-6, plasma cytokines
- MeSH
- humans, burns, cholesterol, blood glucose, fat emulsions, intravenous, fatty acids, linoleic acid, triglycerides, phospholipids, plant oils, liver function tests, parenteral nutrition, total, prospective studies, double-blind method, adult, middle aged, female, male, olive oil
7 autores
- Abelardo García‐de‐Lorenzo🇪🇸 · autor de correspondenciaHospital Universitario La Paz
- R. Denia🇪🇸Hospital Universitario La Paz
- Philippe Atlan🇫🇷Baxter (France)
- S. Martinez-Ratero🇪🇸Hospital Universitario La Paz
- Alexia Le Brun🇫🇷Baxter (France)
- D Evard🇫🇷Baxter (France)
- Gilbert Bereziat🇫🇷Hôpital Saint-Antoine; Laboratoire de Biochimie
Resumen
El texto original del estudio, en el idioma en que se publicó.
It has been claimed that lipid emulsions with a restricted linoleic acid content can improve the safety of total parenteral nutrition (TPN). The tolerability of TPN and its effects on the metabolism of fatty acids were assessed in this prospective, double-blind, randomised study comparing an olive/soyabean oil long-chain triacylglycerol (LCT) with a medium-chain triacylglycerol (MCT)/LCT; 50:50 (w) based lipid emulsion in two groups (O and M, respectively; eleven per group) of severely burned patients. After resuscitation (48-72 h), patients received TPN providing 147 kJ/kg per d (35 kcal/kg per d) with fat (1.3 g/kg per d) for 6 d Plasma fatty acids, laboratory parameters including liver function tests, and plasma cytokines were assessed before and after TPN. Adverse events encountered during TPN and the clinical outcomes of patients within the subsequent 6 months were recorded. With both lipid emulsions, the conversion of linoleic acid in its higher derivatives (di-homo-gamma-linolenic acid) improved and essential fatty acid deficiency did not appear. Abnormalities of liver function tests occurred more frequently in the M (nine) than in the O (three) group (P = 0.04, Suissa-Shuster test). Seven patients (four from group O and three from group M) died as a consequence of severe sepsis 3-37 d after completion of the 6 d TPN period. When compared with the surviving patients, those who died were older (P = 0.01) and hyperglycaemic at baseline (P < 0.001), and their plasma IL-6 levels continued to increase (P < 0.04). Although fatty acid metabolism and TPN tolerability were similar with both lipid emulsions, the preservation of liver function noted with the use of the olive oil-based lipid emulsions deserves confirmation.
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