Caffeine ingestion and lower urinary tract symptoms in healthy volunteers
Bird ET, Parker BD, Kim HS, Coffield KS
Neurourology and urodynamics · 29 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-01-01 · Neurourol Urodyn · vol. 24 · número 7 · págs. 611–615
- Editorial
- Wiley
- Citado
- 45 citas · más que el 88% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 8 trabajos
- Acceso
- De pago
- Áreas de investigación
- Urinary Bladder and Prostate Research · Coffee research and impacts · Urinary Tract Infections Management
- Palabras clave
- caffeine, lower urinary tract symptoms, diuresis, voiding frequency, urine output, healthy volunteers, caffeine dose, urinary symptoms
- MeSH
- urine, humans, caffeine, double-blind method, diuresis, urination, urodynamics, adult, middle aged, female, male, surveys and questionnaires
4 autores
- Erin T. Bird🇺🇸 · autor de correspondenciaTexas A&M University System; Baylor Scott & White Medical Center - Temple; Scott & White Memorial Hospital
- Brian D. Parker🇺🇸Texas A&M University System; Baylor Scott & White Medical Center - Temple; Scott & White Memorial Hospital
- Hyun Sun Kim🇺🇸Texas A&M University System; Scott & White Memorial Hospital
- King Scott Coffield🇺🇸Texas A&M University System; Baylor Scott & White Medical Center - Temple; Scott & White Memorial Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To assess lower urinary tract symptoms (LUTS) after caffeine ingestion in healthy volunteers.
Materials and methods
We conducted a randomized, double-blind, placebo-controlled trial utilizing healthy adult volunteers without urinary tract disease. Caffeine dosage was based on patient weight (equivalent to a 70 kg person taking 200 mg of caffeine twice a day). After a 24-hr washout period, subjects ingested tablets (placebo and drug were identical in appearance) twice a day for 3 days. All participants completed volume-frequency diaries and a post-study symptom questionnaire. Statistical analysis was performed using SAS (version 8.2). Differences voiding frequency and volume were assessed by Wilcoxon rank sum test. The designated level of statistical significance was P < 0.05.
Results
During the first day on study medications, patients taking caffeine versus placebo voided a mean of 7.8 versus 6.4 times in a 24-hr period, respectively, P = 0.05. The mean total urine production was 2,004 ml (caffeine) versus 1,643 ml (placebo), P = 0.06, while total fluid ingested was similar (2,246 ml-caffeine, 2,102 ml-placebo, P = 0.46). For the remaining 2 days there was no significant difference between the two arms. The post-study questionnaire revealed no differences in symptom perception between the two groups.
Conclusions
In healthy volunteers caffeine appears to produce an initial diuresis, but does not appear to have other significant or sustaining effects on lower urinary symptoms in this 4-day model.
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