Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB
Circulation · 277 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Wageningen University and Research
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (K08-HL-075628)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2005-09-20 · Circulation · vol. 112 · número 13 · págs. 1945–1952
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 399 citas · más que el 100% de estudios similares · 19.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Heart Rate Variability and Autonomic Control · Cardiac electrophysiology and arrhythmias
- Palabras clave
- fish oil, omega-3 fatty acids, heart rate, cardiac electrophysiology, baseline heart rate, treatment duration, dose-response relationship, sudden cardiac death, sinoatrial node, autonomic function
- MeSH
- humans, fish oils, double-blind method, heart rate, adult, aged, middle aged, randomized controlled trials as topic
6 autores
- Dariush Mozaffarian🇺🇸🇳🇱Brigham and Women's Hospital; Harvard University; Wageningen University & Research
- Anouk Geelen🇺🇸🇳🇱Brigham and Women's Hospital; Harvard University; Wageningen University & Research
- Ingeborg A. Brouwer🇺🇸🇳🇱Brigham and Women's Hospital; Harvard University; Wageningen University & Research
- Johanna Marianne Geleijnse🇺🇸🇳🇱Brigham and Women's Hospital; Harvard University; Wageningen University & Research
- Peter L. Zock🇺🇸🇳🇱Brigham and Women's Hospital; Harvard University; Wageningen University & Research
- Mira Katan🇺🇸🇳🇱Brigham and Women's Hospital; Harvard University; Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans.
Methods and results
Randomized trials of fish oil that evaluated HR were identified through MEDLINE (1966 through January 2005), hand-searching of references, and contact with investigators for unpublished results. Two investigators independently extracted trial data. A pooled estimate was calculated from random-effects meta-analysis. Predefined stratified meta-analyses and meta-regression were used to explore potential heterogeneity. Of 197 identified articles, 30 met inclusion criteria. Evidence for publication bias was not present. In the overall pooled estimate, fish oil decreased HR by 1.6 bpm (95% CI, 0.6 to 2.5; P=0.002) compared with placebo. Between-trial heterogeneity was evident (Q test, P or =69 bpm (median) but had little effect (0.04-bpm reduction; P=0.56) in trials with baseline HR or =12 weeks but had less effect (0.7-bpm reduction; P=0.27) in trials with duration 0.25 for each).
Conclusions
In randomized controlled trials in humans, fish oil reduces HR, particularly in those with higher baseline HR or longer treatment duration. These findings provide firm evidence that fish oil consumption directly or indirectly affects cardiac electrophysiology in humans. Potential mechanisms such as effects on the sinus node, ventricular efficiency, or autonomic function deserve further investigation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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