Magnesium supplementation and muscle function in patients with alcoholic liver disease: a randomized, placebo-controlled trial
Aagaard NK, Andersen H, Vilstrup H, Clausen T, Jakobsen J, Dørup I
Scandinavian journal of gastroenterology · 14 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-01-01 · Scand J Gastroenterol · vol. 40 · número 8 · págs. 972–979
- Editorial
- Taylor & Francis
- Citado
- 19 citas · más que el 77% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Nutrition and Health in Aging · Alcoholism and Thiamine Deficiency
- Palabras clave
- magnesium supplementation, alcoholic liver disease, muscle strength, muscle mass, skeletal muscle, Na+/K+-ATPase, spironolactone, intravenous magnesium, oral magnesium
- MeSH
- muscle, skeletal, humans, liver diseases, alcoholic, magnesium, biopsy, treatment outcome, administration, oral, injections, intravenous, follow-up studies, prospective studies, muscle contraction, adult, middle aged, female, male
6 autores
- Niels Kristian Aagaard🇩🇰 · autor de correspondenciaAarhus University Hospital
- Henning Andersen🇩🇰Aarhus University Hospital
- Hendrik Vilstrup🇩🇰Aarhus University Hospital
- Torben Clausen🇩🇰Aarhus University
- Johannes Jakobsen🇩🇰Aarhus University Hospital
- I Dørup🇩🇰Aarhus University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The study was undertaken in order to evaluate the effect of magnesium (Mg) supplementation on muscle contents of Mg, muscle strength, muscle mass and sodium, potassium pumps (Na,K-pumps) in patients with alcoholic liver disease. Retrospectively, patients were also stratified according to spironolactone treatment.
Material and methods
The study comprised a placebo-controlled, randomized trial in which 59 consecutive patients with alcoholic liver disease were treated with Mg intravenously and orally (12.5 mmol daily) or placebo for 6 weeks. Muscle content of Mg, maximum isokinetic muscle strength, skeletal muscle mass and muscle content of Na,K-pumps were measured before and after Mg supplementation.
Results
Muscle Mg did not increase during the trial (paired t-test), but Mg supplementation and the duration of pre-study spironolactone treatment were independent predictors of muscle Mg (multiple regression). Muscle strength increased by 14% during the trial (p<0.001) and muscle mass increased by 11% (p=0.05), but with no difference between placebo and Mg treatment. Spironolactone treatment was associated with a 33% increase in the content of Na,K-pumps (p<0.001).
Conclusions
Six weeks of Mg supplementation did not increase muscle Mg, although Mg supplementation and spironolactone treatment were independent predictors of muscle Mg. The intervention had no effect on muscle strength and mass, but both increased during the study, probably owing to the general care and attendance to the patients.
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