Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants
Lauritzen L, Jørgensen MH, Olsen SF, Straarup EM, Michaelsen KF
Reproduction, nutrition, development · 87 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- San Diego State University
- Universidad u hospital
- University of Dundee
- Universidad u hospital
- Syddansk Universitet
Según 3 financiadores declarados.
Publicación
- Publicado
- 2005-09-01 · Reprod Nutr Dev · vol. 45 · número 5 · págs. 535–547
- Editorial
- Elsevier BV
- Citado
- 135 citas · más que el 97% de estudios similares · 6.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Breastfeeding Practices and Influences
- Palabras clave
- docosahexaenoic acid, breast milk, lactation, breast-fed infants, infant language development, receptive vocabulary, word comprehension, problem-solving skills, olive oil, infant development
- MeSH
- erythrocytes, milk, human, humans, fatty acids, omega-3, docosahexaenoic acids, arachidonic acid, fish oils, cohort studies, double-blind method, child development, language development, problem solving, breast feeding, lactation, pregnancy, visual acuity, dietary supplements, infant food, adult, infant, infant, newborn, denmark, female, male, infant nutritional physiological phenomena
5 autores
- Lotte Lauritzen
- Marianne Hørby Jørgensen🇩🇰Rigshospitalet
- Sjurdur Frodi Olsen🇩🇰Statens Serum Institut
- Ellen Marie Straarup🇩🇰Technical University of Denmark
- Kim F. Michaelsen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Docosahexaenoic acid (DHA) accumulates in the brain during the 1st and 2nd years of life. The objective of this study was to see if an increased content of DHA in breast-milk via maternal fish oil (FO)-supplementation affects mental development in term infants. one hundred twenty-two Danish mothers with a habitual fish intake below the population median were randomized to 4.5 g.d(-1) of FO or olive oil (OO) for the first four months of lactation. Fifty-three mothers with habitual fish intake in the highest quartile were included as reference group. The effect of the resulting increase in infant DHA-intake and RBC-DHA level was assessed on problem solving ability at nine months and language at one and two years of age. Infants in the three groups performed equally well on the problem test and no association was observed between problem solving and erythrocyte-DHA at four months. Passive vocabulary at one year was lower in the children of the FO- compared with the OO-group (P < 0.05), but no differences were found at two years of age. Word comprehension at one year was inversely associated with erythrocyte-DHA at four months. The trial indicate a small effect of DHA levels in breast-milk on early language development of breast-fed infants.
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