Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels
Lovallo WR, Whitsett TL, al'Absi M, Sung BH, Vincent AS, Wilson MF
Psychosomatic medicine · 99 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01 RR-14467); National Heart, Lung, and Blood Institute (HL32050); National Center for Research Resources (M01RR014467); National Heart, Lung, and Blood Institute (R01HL032050)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2005-09-01 · Psychosom Med · vol. 67 · número 5 · págs. 734–739
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 151 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Stress Responses and Cortisol · Circadian rhythm and melatonin
- Palabras clave
- caffeine, cortisol secretion, caffeine tolerance, caffeine consumption, caffeine abstinence, diurnal cortisol rhythm, salivary cortisol, stress response, healthy young adults
- MeSH
- humans, caffeine, hydrocortisone, central nervous system stimulants, capsules, placebos, cross-over studies, double-blind method, wakefulness, secretory rate, circadian rhythm, dose-response relationship, drug, drug tolerance, adult, female, male
6 autores
- William R. Lovallo🇺🇸 · autor de correspondenciaUniversity of Minnesota; Kaleida Health; Oklahoma City VA Medical Center; National Heart, Lung, and Blood Institute; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
- Thomas L. Whitsett🇺🇸University of Minnesota; Kaleida Health; National Heart, Lung, and Blood Institute; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
- Mustafa Al’Absi🇺🇸University of Minnesota; Kaleida Health; National Heart, Lung, and Blood Institute; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
- Bong Hee Sung🇺🇸University of Minnesota; Kaleida Health; National Heart, Lung, and Blood Institute; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
- Andrea S. Vincent🇺🇸University of Minnesota; Kaleida Health; National Heart, Lung, and Blood Institute; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
- Michael F. Wilson🇺🇸University of Minnesota; Kaleida Health; National Heart, Lung, and Blood Institute; University of Minnesota, Duluth; University of Oklahoma Health Sciences Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Caffeine increases cortisol secretion in people at rest or undergoing mental stress. It is not known whether tolerance develops in this response with daily intake of caffeine in the diet. We therefore tested the cortisol response to caffeine challenge after controlled levels of caffeine intake.
Methods
Men (N = 48) and women (N = 48) completed a double-blind, crossover trial conducted over 4 weeks. On each week, subjects abstained for 5 days from dietary caffeine and instead took capsules totaling 0 mg, 300 mg, and 600 mg/day in 3 divided doses. On day 6, they took capsules with either 0 mg or 250 mg at 9:00 AM, 1:00 PM, and 6:00 PM, and cortisol was sampled from saliva collected at 8 times from 7:30 AM to 7:00 PM.
Results
After 5 days of caffeine abstinence, caffeine challenge doses caused a robust increase in cortisol across the test day (p < .0001). In contrast, 5 days of caffeine intake at 300 mg/day and 600 mg/day abolished the cortisol response to the initial 9:00 AM caffeine dose, although cortisol levels were again elevated between 1:00 PM and 7:00 PM (p = .02 to .002) after the second caffeine dose taken at 1:00 PM. Cortisol levels declined to control levels during the evening sampling period.
Conclusion
Cortisol responses to caffeine are reduced, but not eliminated, in healthy young men and women who consume caffeine on a daily basis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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