Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter
Romieu I, Téllez-Rojo MM, Lazo M, Manzano-Patiño A, Cortez-Lugo M, Julien P, Bélanger MC, Hernandez-Avila M, Holguin F
American journal of respiratory and critical care medicine · 97 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-10-06 · Am J Respir Crit Care Med · vol. 172 · número 12 · págs. 1534–1540
- Editorial
- American Thoracic Society
- Citado
- 136 citas · más que el 95% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Heart Rate Variability and Autonomic Control · Air Quality and Health Impacts
- Palabras clave
- omega-3 fatty acids, fish oil supplementation, particulate matter, PM2.5, heart rate variability, air pollution exposure, nursing home residents, older adults, autonomic nervous system, respiratory syncytial virus
- MeSH
- humans, fatty acids, omega-3, soybean oil, fish oils, air pollutants, double-blind method, heart rate, particle size, dietary supplements, aged, aged, 80 and over, urban health, nursing homes, mexico, female, male
9 autores
- Isabelle Romieu🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Martha María Téllez‐Rojo🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Mariana Lazo🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Abigail P Manzano-Patiño🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Marlene Cortez‐Lugo🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Pierre Julien🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Marie–Claire Bélanger🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Mauricio Hernández‐Ávila🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
- Fernando Holguín🇺🇸🇲🇽🇨🇦Emory University; Instituto Nacional de Salud Pública; Université Laval
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Environmental exposure to particulate matter of 2.5 microm or less (PM2.5) has been associated with changes in heart rate variability (HRV).
Objective
To evaluate the effect of supplementation with omega-3 polyunsaturated fatty acids on the reduction of HRV associated with PM2.5 exposure.
Design
Randomized double-blind trial.
Setting
Mexico City, Mexico.
Participants
50 nursing home residents older than 60 yr.
Intervention
Randomization to either 2 g/d of fish oil versus 2 g/d of soy oil as the control, with 6 mo follow-up (1-mo presupplementation and 5-mo supplementation) or repeated HRV measurements. PM2.5 was monitored indoors and outdoors.
Main outcome measure
The association between HRV and 1 SD change in PM2.5 (8 microg/m3).
Results
In the group receiving fish oil, the reduction in HRV-high-frequency log(10)-transformed associated with a 1-SD change in PM2.5 was -54% (95% confidence interval, -72, -24) in the presupplementation phase, and only -7% (95% confidence interval, -20,+7) in the supplementation phase (p < 0.01 for the effect of supplementation), with changes in other HRV parameters also being significantly less pronounced during supplementation. Small decreases in PM2.5-associated reductions in HRV parameters also occurred in the group receiving soy oil, but these were not significant. Fish oil supplementation was significantly better in preventing the reduction in percentage of successive normal RR intervals differing by more than 50 ms (p = 0.03) and the root square of the mean of the sum of the squares of differences between adjacent intervals (p = 0.05) than soy oil supplementation.
Interpretation
Supplementation with 2 g/d of fish oil prevented HRV decline related to PM2.5 exposure in the study population.
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