Dietary magnesium intake and risk of cardiovascular disease among women
Song Y, Manson JE, Cook NR, Albert CM, Buring JE, Liu S
The American journal of cardiology · 65 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (CA-47988); National Heart, Lung, and Blood Institute (HL43851); National Institute of Diabetes and Digestive and Kidney Diseases (DK 66401)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2005-08-30 · Am J Cardiol · vol. 96 · número 8 · págs. 1135–1141
- Editorial
- Elsevier BV
- Citado
- 99 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, cardiovascular disease, myocardial infarction, stroke, coronary artery disease, cardiovascular mortality, women, female health workers, CVD risk factors
- MeSH
- humans, cardiovascular diseases, myocardial infarction, magnesium, diet, confidence intervals, risk factors, double-blind method, adult, aged, middle aged, women's health, female, stroke
6 autores
- Yiqing Song🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Nancy R. Cook🇺🇸Brigham and Women's Hospital; Harvard University
- Christine M. Albert🇺🇸Brigham and Women's Hospital; Harvard University; Massachusetts General Hospital
- Julie E. Buring🇺🇸Brigham and Women's Hospital; Harvard University
- Simin Liu🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study assessed the hypothesis that greater magnesium intake is associated with reduced risk for cardiovascular disease (CVD), including myocardial infarction (MI) and stroke, in a large prospective cohort of women. In 1993, a semi-quantitative food frequency questionnaire was used to assess magnesium intake in 39,876 female health professionals aged 39 to 89 years who had no history of CVD or cancer. During a median of 10 years of follow-up, 1,037 incident cases of CVD were identified, including 280 nonfatal MIs and 368 strokes. After adjustment for age and randomized treatment status, magnesium intake was not significantly associated with risk for incident CVD. Comparing the highest quintile of magnesium intake (median 433 mg/day) with the lowest quintile (median 255 mg/day), the relative risks were 0.87 (95% confidence interval [CI] 0.72 to 1.05, p for trend = 0.24) for total CVD, 0.88 (95% CI 0.70 to 1.12, p for trend = 0.34) for coronary heart disease (CHD), 1.03 (95% CI 0.72 to 1.49, p for trend = 0.96) for nonfatal MI, 1.11 (95% CI 0.61 to 2.00, p for trend = 0.95) for CVD death, and 0.87 (95% CI 0.64 to 1.18, p for trend = 0.55) for total stroke. Additional adjustment for other CVD risk factors did not materially change the observed null associations. In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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