Caffeine effects on resting-state arousal
Barry RJ, Rushby JA, Wallace MJ, Clarke AR, Johnstone SJ, Zlojutro I
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 131 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-10-11 · Clin Neurophysiol · vol. 116 · número 11 · págs. 2693–2700
- Editorial
- Elsevier BV
- Citado
- 190 citas · más que el 93% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Neural dynamics and brain function · Attention Deficit Hyperactivity Disorder
- Palabras clave
- caffeine, arousal, skin conductance level, EEG alpha power, alpha frequency, autonomic arousal, cardiovascular effects, attention deficit hyperactivity disorder, hyperarousal, hypoarousal
- MeSH
- humans, caffeine, central nervous system stimulants, electroencephalography, alpha rhythm, cross-over studies, double-blind method, arousal, galvanic skin response, rest, adult, female, male
6 autores
- Robert J. Barry🇦🇺 · autor de correspondenciaUniversity of Wollongong
- Jacqueline Ann Rushby🇦🇺University of Wollongong
- Mark J. Wallace🇦🇺University of Wollongong
- Adam R. Clarke🇦🇺University of Wollongong
- Stuart John Johnstone🇦🇺University of Wollongong
- I ZLOJUTRO🇦🇺University of Wollongong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study examined the use of caffeine to manipulate arousal level without the confounds associated with task-related activation. From previous work in our laboratory, an increase in skin conductance level (SCL) and EEG alpha frequency, together with a global decrease in alpha power, were used as markers of arousal increase, and we sought to identify these effects with caffeine ingestion.
Methods
We examined the effect of a single oral dose of caffeine (250 mg) in a randomised double-blind placebo-controlled repeated-measures cross-over study. Eighteen healthy university students (mean age 21 years; 13/18 females) participated in two sessions 1 week apart. EEG and autonomic data (SCL, heart rate, systolic and diastolic blood pressure, and respiration rate) from a 2 min eyes-closed epoch, commencing approximately 30 min after ingestion of caffeine or placebo, were examined.
Results
Caffeine was associated with increased SCL, a global reduction in EEG power in the alpha band, and a global increase in alpha frequency. There were no cardiovascular effects.
Conclusions
The positive results are consistent with recent electrodermal and EEG studies of arousal and suggest that caffeine may be utilised as a task-free means of manipulating arousal in future investigations. Further work is necessary to clarify the absence of cardiovascular effects, and to integrate those data with emerging conceptualisations of arousal and activation.
Significance
The present data support the use of caffeine as a simple tool to explore the role of arousal in both normal and atypical functioning, and this may be useful in determining the validity and importance of supposed hyper- or hypo-arousal in such syndromes as attention-deficit/hyperactivity disorder (AD/HD).
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