Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial
Flicker L, MacInnis RJ, Stein MS, Scherer SC, Mead KE, Nowson CA, Thomas J, Lowndes C, Hopper JL, Wark JD
Journal of the American Geriatrics Society · 179 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-09-15 · J Am Geriatr Soc · vol. 53 · número 11 · págs. 1881–1888
- Editorial
- Wiley
- Citado
- 305 citas · más que el 99% de estudios similares · 13.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Geriatric Care and Nursing Homes
- Palabras clave
- vitamin D supplementation, fall prevention, fracture, older adults, residential care, nursing homes, assisted living, vitamin D2, calcium supplementation, vitamin D deficiency, 25-hydroxyvitamin D
- MeSH
- humans, calcium carbonate, ergocalciferols, drug administration schedule, geriatric assessment, odds ratio, follow-up studies, prospective studies, patient compliance, accidental falls, dose-response relationship, drug, aged, aged, 80 and over, frail elderly, residential facilities, homes for the aged, nursing homes, victoria, female, male, fractures, bone
10 autores
- Leon A Flicker🇦🇺The University of Western Australia
- Robert J. MacInnis🇦🇺The University of Western Australia
- Mark S. Stein🇦🇺The University of Western Australia
- Sam C. Scherer🇦🇺The University of Western Australia
- Kate E. Mead🇦🇺The University of Western Australia
- Caryl Anne Nowson🇦🇺The Royal Melbourne Hospital; Deakin University; The University of Melbourne; The University of Western Australia; Cancer Council Victoria
- Jenny Thomas🇦🇺The Royal Melbourne Hospital; Deakin University; The University of Melbourne; The University of Western Australia; Cancer Council Victoria
- Chris Lowndes🇦🇺The Royal Melbourne Hospital; Deakin University; The University of Melbourne; The University of Western Australia; Cancer Council Victoria
- John Llewelyn Hopper🇦🇺The Royal Melbourne Hospital; Deakin University; The University of Melbourne; The University of Western Australia; Cancer Council Victoria
- John Dennis Wark🇦🇺The University of Western Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine whether vitamin D supplementation can reduce the incidence of falls and fractures in older people in residential care who are not classically vitamin D deficient.
Design
Randomized, placebo-controlled double-blind, trial of 2 years' duration.
Setting
Multicenter study in 60 hostels (assisted living facilities) and 89 nursing homes across Australia.
Participants
Six hundred twenty-five residents (mean age 83.4) with serum 25-hydroxyvitamin D levels between 25 and 90 nmol/L.
Intervention
Vitamin D supplementation (ergocalciferol, initially 10,000 IU given once weekly and then 1,000 IU daily) or placebo for 2 years. All subjects received 600 mg of elemental calcium daily as calcium carbonate.
Measurements
Falls and fractures recorded prospectively in study diaries by care staff.
Results
The vitamin D and placebo groups had similar baseline characteristics. In intention-to-treat analysis, the incident rate ratio for falling was 0.73 (95% confidence interval (CI)=0.57-0.95). The odds ratio for ever falling was 0.82 (95% CI=0.59-1.12) and for ever fracturing was 0.69 (95% CI=0.40-1.18). An a priori subgroup analysis of subjects who took at least half the prescribed capsules (n=540), demonstrated an incident rate ratio for falls of 0.63 (95% CI=0.48-0.82), an odds ratio (OR) for ever falling of 0.70 (95% CI=0.50-0.99), and an OR for ever fracturing of 0.68 (95% CI=0.38-1.22).
Conclusion
Older people in residential care can reduce their incidence of falls if they take a vitamin D supplement for 2 years even if they are not initially classically vitamin D deficient.
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