Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol
Lefevre M, Champagne CM, Tulley RT, Rood JC, Most MM
The American journal of clinical nutrition · 59 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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- Resultado principal
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-11-01 · Am J Clin Nutr · vol. 82 · número 5 · págs. 957–963
- Editorial
- Elsevier BV
- Citado
- 104 citas · más que el 97% de estudios similares · 7.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Fatty Acid Research and Health
- Palabras clave
- LDL cholesterol, low-fat diet, low saturated fat diet, insulin resistance, adiposity, body mass index, plasma lipids, HDL cholesterol, triglycerides, cardiovascular risk, dietary fat reduction, men
- MeSH
- adipose tissue, humans, cardiovascular diseases, insulin resistance, obesity, insulin, dietary fats, triglycerides, body mass index, diet, fat-restricted, risk factors, cross-over studies, double-blind method, adult, middle aged, male, cholesterol, ldl, cholesterol, hdl
5 autores
- Michael L LeFevre🇺🇸 · autor de correspondenciaPennington Biomedical Research Center
- Catherine M. Champagne🇺🇸Pennington Biomedical Research Center
- Richard T. Tulley🇺🇸Pennington Biomedical Research Center
- Jennifer Carlton Rood🇺🇸Pennington Biomedical Research Center
- Marlene M. Most🇺🇸Pennington Biomedical Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although reductions in total and saturated fat consumption are recommended to reduce the risk of cardiovascular disease, individual variability in plasma lipid responses exists.
Objective
Our aim was to determine the effect of adiposity and insulin resistance on the lipoprotein response to diets lower in total and saturated fat than the average American diet (AAD).
Design
A randomized, double-blind, 3-period crossover controlled feeding design was used to examine the effects on plasma lipids of 3 diets that differed in total fat: the AAD [designed to contain 38% fat and 14% saturated fatty acids (SFAs)], the Step I diet (30% fat with 9% SFAs), and the Step II diet (25% fat with 6% SFAs). The diets were fed for 6 wk each to 86 free-living, healthy men aged 22-64 y at levels designed to maintain weight.
Results
Compared with the AAD, the Step I and Step II diets lowered LDL cholesterol by 6.8% and 11.7%, lowered HDL cholesterol by 7.5% and 11.2%, and raised triacylglycerols by 14.3% and 16.2%, respectively. The Step II diet response showed significant positive correlations between changes in both LDL cholesterol and the ratio of total to HDL cholesterol and baseline percentage body fat, body mass index, and insulin. These associations were largely due to smaller reductions in LDL cholesterol with increasing percentage body fat, body mass index, or insulin concentrations. Subdivision of the study population showed that the participants in the upper one-half of fasting insulin concentrations averaged only 57% of the reduction in LDL cholesterol with the Step II diet of the participants in the lower half.
Conclusion
Persons who are insulin resistant respond less favorably to Step II diets than do those who are insulin sensitive.
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