Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial
Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F
The American journal of clinical nutrition · 134 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-11-01 · Am J Clin Nutr · vol. 82 · número 5 · págs. 1115–1126
- Editorial
- Elsevier BV
- Citado
- 221 citas · más que el 99% de estudios similares · 10.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Nutrition and Health Studies
- Palabras clave
- calcium supplementation, vitamin D supplementation, bone accrual, body composition, dairy products, cheese, dietary calcium, vitamin D3, cortical bone thickness, tibia, hip bone density, spine bone mineral density, children
- MeSH
- radius, tibia, humans, calcium, dietary, vitamin d, absorptiometry, photon, analysis of variance, linear models, double-blind method, patient compliance, bone remodeling, body composition, bone development, puberty, menarche, bone density, dairy products, cheese, dietary supplements, child, female, bone density conservation agents
16 autores
- Sulin Cheng🇫🇮🇺🇸🇸🇪 · autor de correspondenciaUniversity of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Gothenburg; University of Jyväskylä
- Arja Lyytikäinen🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Heikki Kröger🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Christel J. E. Lamberg-Allardt🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Markku Alén🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Arvo Koistinen🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Qing Ju Wang🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Miia Suuriniemi🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Harri Suominen🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Anitta Mahonen🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Patrick Nicholson🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Kaisa K. Ivaska🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Riitta Korpela🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Claes Ohlsson🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Kalervo Väänänen🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
- Frances A. Tylavsky🇫🇮🇺🇸🇸🇪University of Helsinki; University of Turku; University of Tennessee Health Science Center; Kuopio University Hospital; Valio (Finland); Central Finland Health Care District; University of Tennessee at Knoxville; University of Gothenburg; University of Jyväskylä
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period.
Objective
The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y.
Design
This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography.
Results
With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared.
Conclusions
Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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