Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, Carmella SG, Hecht SS, Benning L, Gange SJ, Groopman JD, Talalay P
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 232 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NCI NIH HHS
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Cancer Institute (R01 CA93780); National Cancer Institute (R01 CA 92025); National Institute of Environmental Health Sciences (P01-ES06052); National Institute of Environmental Health Sciences (ES03819); National Cancer Institute (R21 CA 098485)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2005-11-01 · Cancer Epidemiol Biomarkers Prev · vol. 14 · número 11 · págs. 2605–2613
- Editorial
- American Association for Cancer Research
- Citado
- 317 citas · más que el 97% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Mycotoxins in Agriculture and Food
- Palabras clave
- broccoli sprouts, glucosinolates, glucoraphanin, sulforaphane, aflatoxin-DNA adducts, dithiocarbamates, chemoprevention, hepatocellular carcinoma, aflatoxin exposure, urinary biomarkers, cruciferous vegetables, Qidong
- MeSH
- humans, brassica, carcinoma, hepatocellular, liver neoplasms, phenanthrenes, glucosinolates, dna adducts, anticarcinogenic agents, aflatoxins, placebos, hydrolysis, biological availability, beverages, adult, aged, middle aged, female, male
21 autores
- Thomas W. Kensler🇺🇸🇬🇧Johns Hopkins University; Environmental Health
- Jianguo Chen🇨🇳Qidong Liver Cancer Prevention Research
- Patricia A. Egner🇺🇸🇬🇧Johns Hopkins University; Environmental Health
- Jed W. Fahey🇺🇸Johns Hopkins University
- Lisa P. Jacobson
- Katherine K. Stephenson🇺🇸Johns Hopkins University
- Lingxiang Ye🇺🇸Johns Hopkins University
- Jamie L. Coady🇺🇸🇬🇧Johns Hopkins University; Environmental Health
- Jin-Bing Wang🇨🇳Qidong Liver Cancer Prevention Research
- Yan Wu🇨🇳Qidong Liver Cancer Prevention Research
- Yan Sun🇨🇳Qidong Liver Cancer Prevention Research
- Qi-Nan Zhang🇨🇳Qidong Liver Cancer Prevention Research
- Bao-Chu Zhang🇨🇳Qidong Liver Cancer Prevention Research
- Yuan-Rong Zhu🇨🇳Qidong Liver Cancer Prevention Research
- Geng-Sun Qian🇨🇳Shanghai Jiao Tong University; Shanghai Cancer Institute
- Stephen G. Carmella🇺🇸University of Minnesota
- Stephen S. Hecht🇺🇸University of Minnesota
- Lorie Benning🇺🇸Johns Hopkins University
- Stephen J. Gange
- John D. Groopman🇬🇧Environmental Health
- Paul Talalay🇺🇸Johns Hopkins University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of aflatoxin-contaminated foods, and are exposed to high levels of phenanthrene, a sentinel of hydrocarbon air toxics. Cruciferous vegetables, such as broccoli, contain anticarcinogens. Glucoraphanin, the principal glucosinolate in broccoli sprouts, can be hydrolyzed by gut microflora to sulforaphane, a potent inducer of carcinogen detoxication enzymes. In a randomized, placebo-controlled chemoprevention trial, we tested whether drinking hot water infusions of 3-day-old broccoli sprouts, containing defined concentrations of glucosinolates, could alter the disposition of aflatoxin and phenanthrene. Two hundred healthy adults drank infusions containing either 400 or < 3 micromol glucoraphanin nightly for 2 weeks. Adherence to the study protocol was outstanding; no problems with safety or tolerance were noted. Urinary levels of aflatoxin-N(7)-guanine were not different between the two intervention arms (P = 0.68). However, measurement of urinary levels of dithiocarbamates (sulforaphane metabolites) indicated striking interindividual differences in bioavailability. An inverse association was observed for excretion of dithiocarbamates and aflatoxin-DNA adducts (P = 0.002; R = 0.31) in individuals receiving broccoli sprout glucosinolates. Moreover, trans, anti-phenanthrene tetraol, a metabolite of the combustion product phenanthrene, was detected in urine of all participants and showed a robust inverse association with dithiocarbamate levels (P = 0.0001; R = 0.39), although again no overall difference between intervention arms was observed (P = 0.29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions.
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