Multiple caffeine doses maintain vigilance during early morning operations
Kamimori GH, Johnson D, Thorne D, Belenky G
Aviation, space, and environmental medicine · 35 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-11-01 · Aviat Space Environ Med · vol. 76 · número 11 · págs. 1046–50
- Editorial
- National Institutes of Health
- Citado
- 71 citas · más que el 94% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Coffee research and impacts · Mind wandering and attention
- Palabras clave
- caffeine, sleep deprivation, sustained attention, psychomotor performance, sleepiness, Stanford Sleepiness Scale, psychomotor vigilance test, caffeine dose-response
- MeSH
- humans, sleep deprivation, caffeine, central nervous system stimulants, drug administration schedule, analysis of variance, double-blind method, psychomotor performance, aerospace medicine, dose-response relationship, drug, chewing gum, female, male
4 autores
- Gary H. Kamimori🇺🇸Walter Reed Army Institute of Research
- Dagny E Johnson
- David Thorne
- Gregory Lucas Belenky
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
When used to counteract the effects of sleep deprivation, multiple doses of caffeine are typically ingested across an extended period of time. The goal of this study was to determine the optimal dose of caffeine for sustaining performance during sleep loss with administration of multiple doses.
Methods
There were 48 subjects (28 men, 20 women) who were randomly assigned to 1 of 4 groups (placebo, 50, 100, or 200 mg caffeine). After an overnight 8-h sleep period, subjects were required to remain awake for the ensuing 29 h. Control data were collected until 03:00 (Day 3), followed by three 2-h test blocks. At 03:00, 05:00, and 07:00 subjects chewed two sticks of gum (Stay Alerts chewing gum) containing caffeine or placebo. Six 10-min sessions on a version of the Psychomotor Vigilance Test (PVT) were completed during each 2-h test block. The Stanford Sleepiness Scale (SSS) was administered after each PVT.
Results
Lapses on the PVT were categorized as response times greater than 1, 3, or 5 s. Lapses in all categories significantly increased in the placebo group. Caffeine significantly reduced the number of lapses in a dose-related manner; and performance was maintained at baseline levels for the entire sleep loss period with multiple doses of 200 mg caffeine. There was a significant main effect for session on the SSS, the score increasing over time, but no significant differences between groups.
Discussion
These results indicate that a bi-hourly administration of 200 mg of caffeine maintains vigilance performance across a single night without sleep.
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