Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge
Greene CM, Zern TL, Wood RJ, Shrestha S, Aggarwal D, Sharman MJ, Volek JS, Fernandez ML
The Journal of nutrition · 63 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-12-01 · J Nutr · vol. 135 · número 12 · págs. 2793–2798
- Editorial
- Elsevier BV
- Citado
- 109 citas · más que el 91% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Nutritional Studies and Diet
- Palabras clave
- dietary cholesterol, eggs, egg substitutes, LDL cholesterol, HDL cholesterol, LDL/HDL ratio, plasma lipids, LDL oxidation, conjugated dienes, older adults, postmenopausal women, cardiovascular risk
- MeSH
- humans, lipids, cholesterol, dietary, triglycerides, lipoproteins, ldl, apolipoproteins, cross-over studies, smoking, blood pressure, eggs, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl
8 autores
- Christine M. Greene🇺🇸University of Connecticut
- Tosca L. Zern
- Richard James Wood
- Sudeep Shrestha
- Dimple Aggarwal
- Matthew J. Sharman🇺🇸University of Connecticut
- Jeff S. Volek🇺🇸University of Connecticut
- María Luz Fernández · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
We previously evaluated the responses to dietary cholesterol in children and young adults. In this study, the effects of dietary cholesterol on plasma lipids and LDL atherogenicity were evaluated in 42 elderly subjects (29 postmenopausal women and 13 men > 60 y old). Our exclusion criteria were diabetes, heart disease, and the use of reductase inhibitors. The study followed a randomized crossover design in which subjects were assigned to consume the equivalent of 3 large eggs (EGG) daily or the same amount of a cholesterol-free, fat-free egg substitute (SUB) for a 1-mo period. After a 3-wk washout period, subjects were assigned to the alternate treatment. The concentration of plasma cholesterol after the EGG period varied among subjects. When all subjects were evaluated, there were significant increases in LDL cholesterol (LDL-C) (P < 0.05) and HDL-C (P < 0.001) for both men and women during the EGG period, resulting in no alterations in the LDL-C:HDL-C or the total cholesterol:HDL-C ratios. In addition, the LDL peak diameter was increased during the EGG period for all subjects. In contrast, the measured parameters of LDL oxidation, conjugated diene formation, and LDL lag time did not differ between the EGG and the SUB periods. We conclude from this study that dietary cholesterol provided by eggs does not increase the risk for heart disease in a healthy elderly population.
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