A 3-month double-blind randomised study comparing an olive oil- with a soyabean oil-based intravenous lipid emulsion in home parenteral nutrition patients
Vahedi K, Atlan P, Joly F, Le Brun A, Evard D, Perennec V, Roux-Haguenau D, Bereziat G, Messing B
The British journal of nutrition · 39 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- European Society for Clinical Nutrition and Metabolism
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-12-01 · Br J Nutr · vol. 94 · número 6 · págs. 909–916
- Editorial
- Cambridge University Press
- Citado
- 54 citas · más que el 88% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Central Venous Catheters and Hemodialysis
- Palabras clave
- intravenous lipid emulsion, olive oil, soybean oil, home parenteral nutrition, essential fatty acid deficiency, gamma-linolenic acid, oleic acid, polyunsaturated fatty acids, long-chain triglycerides, medium-chain triglycerides, intestinal failure, plasma phospholipid fatty acids, fat absorption
- MeSH
- lymphocytes, cell membrane, humans, intestinal diseases, liver diseases, dietary fats, unsaturated, soybean oil, fatty acids, unsaturated, gamma-linolenic acid, oleic acid, plant oils, emulsions, body mass index, parenteral nutrition, home, infusions, intravenous, double-blind method, adult, aged, aged, 80 and over, middle aged, female, male, olive oil
9 autores
- Kouroche Vahedi🇫🇷 · autor de correspondenciaBaxter (France); Hôpital Lariboisière
- Philippe Atlan🇫🇷Baxter (France)
- Francisca Joly🇫🇷Hôpital Lariboisière
- Alexia Le Brun🇫🇷Baxter (France)
- D Evard🇫🇷Baxter (France)
- V. Pérennec🇫🇷Baxter (France)
- D. Roux-Haguenau🇫🇷Hôpital Lariboisière
- Gilbert Bereziat🇫🇷Hôpital Saint-Antoine; Laboratoire de Biochimie
- Bernard Messing🇫🇷Hôpital Lariboisière
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intravenous lipid emulsions (ILE) have demonstrated advantages including prevention of essential fatty acid (EFA) deficiency; however, too much EFA can down regulate fatty acid elongation leading to an imbalance of nutritional compounds in plasma and cell membranes. An olive oil-based ILE containing long-chain triacylglycerols (LCT) with a low content (20 %) of PUFA was administered for home parenteral nutrition (HPN) and compared with a conventional soyabean oil-based ILE (PUFA content, 60 %). Thirteen patients (26-92 years) with stable intestinal failure were randomised after a 1-month run-in period with a medium-chain triacylglycerols-LCT-based ILE, to receive 3 months of HPN with either olive oil- (n 6) or soyabean oil-based (n 7) ILE. The nutritional impact and safety of HPN, oral intakes and absorption rates, phospholipid fatty acids in plasma and lymphocyte cell membrane were assessed. The only clinical event reported was one case of pneumonia (soya group). In both groups, 20 : 3n-9:20 : 4n-6 ratios remained within normal ranges (0.03-0.07). There was a significant increase of gamma-linolenic acid (gamma-LA) in plasma and lymphocyte cell membrane (P=0.02) and of oleic acid in plasma (P<0.01) in the olive compared with the soya group. A significant correlation was found between gamma-LA (day 90 - day 0) in plasma and PUFA parenteral intakes (P=0.02), but neither with fat intakes nor with fat absorption rates. In conclusion, plasma and lymphocyte EFA pattern remained in normal ranges without EFA deficiency with both lipid emulsions, despite a lower content of n-3 and n-6 series with the olive oil-based ILE.
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