A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations
Bjordal JM, Lopes-Martins RA, Lopes-Martins RA, Iversen VV
British journal of sports medicine · 184 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Norges Forskningsråd
Según 1 financiador declarado.
Publicación
- Publicado
- 2005-12-21 · Br J Sports Med · vol. 40 · número 1 · págs. 76–80
- Editorial
- BMJ
- Citado
- 276 citas · más que el 99% de estudios similares · 10.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Tendon Structure and Treatment · Laser Applications in Dentistry and Medicine · Pain Mechanisms and Treatments
- Palabras clave
- low-level laser therapy, Achilles tendinitis, tendinopathy, prostaglandin E2, anti-inflammatory activity, pressure pain threshold, infrared laser, resistance index, pain management
- MeSH
- achilles tendon, humans, dinoprostone, ultrasonography, pain measurement, treatment outcome, microdialysis, double-blind method, adult, middle aged, tendinopathy, low-level light therapy
3 autores
- Jan Magnus Bjordal🇳🇴 · autor de correspondenciaUniversity of Bergen
- Rodrigo Álvaro Brandão Lopes‐Martins🇧🇷Universidade de São Paulo
- Vegard Vereide Iversen🇳🇴University of Bergen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low level laser therapy (LLLT) has gained increasing popularity in the management of tendinopathy and arthritis. Results from in vitro and in vivo studies have suggested that inflammatory modulation is one of several possible biological mechanisms of LLLT action.
Objective
To investigate in situ if LLLT has an anti-inflammatory effect on activated tendinitis of the human Achilles tendon.
Subjects
Seven patients with bilateral Achilles tendinitis (14 tendons) who had aggravated symptoms produced by pain inducing activity immediately before the study.
Method
Infrared (904 nm wavelength) LLLT (5.4 J per point, power density 20 mW/cm2) and placebo LLLT (0 J) were administered to both Achilles tendons in random blinded order.
Results
Ultrasonography Doppler measurements at baseline showed minor inflammation through increased intratendinous blood flow in all 14 tendons and measurable resistive index in eight tendons of 0.91 (95% confidence interval 0.87 to 0.95). Prostaglandin E2 concentrations were significantly reduced 75, 90, and 105 minutes after active LLLT compared with concentrations before treatment (p = 0.026) and after placebo LLLT (p = 0.009). Pressure pain threshold had increased significantly (p = 0.012) after active LLLT compared with placebo LLLT: the mean difference in the change between the groups was 0.40 kg/cm2 (95% confidence interval 0.10 to 0.70).
Conclusion
LLLT at a dose of 5.4 J per point can reduce inflammation and pain in activated Achilles tendinitis. LLLT may therefore have potential in the management of diseases with an inflammatory component.
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