Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression
Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M, Gelenberg AJ
Acta psychiatrica Scandinavica · 129 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Mental Health (R01-MH-60335); National Institute of Mental Health (1 K23 MH66265-01)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2005-10-21 · Acta Psychiatr Scand · vol. 113 · número 1 · págs. 31–35
- Editorial
- Wiley
- Citado
- 199 citas · más que el 99% de estudios similares · 16.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Maternal Mental Health During Pregnancy and Postpartum · Fatty Acid Research and Health · Treatment of Major Depression
- Palabras clave
- postpartum depression, omega-3 fatty acids, dose-ranging, antidepressant treatment, maternal mental health, treatment efficacy, tolerability
- MeSH
- humans, depression, postpartum, fatty acids, omega-3, treatment outcome, drug administration schedule, severity of illness index, mothers, pregnancy, dose-response relationship, drug, diagnostic and statistical manual of mental disorders, adult, female, surveys and questionnaires
6 autores
- Marlene P. Freeman🇺🇸 · autor de correspondenciaUniversity of Arizona; University of Arizona College of Medicine- Phoenix
- Joseph R. Hibbeln🇺🇸National Institute on Alcohol Abuse and Alcoholism
- Katherine L. Wisner🇺🇸University of Pittsburgh; University of Pittsburgh Medical Center
- Barbara Hagenah Brumbach🇺🇸University of Arizona
- Marcy Watchman🇺🇸University of Arizona; University of Arizona College of Medicine- Phoenix
- Alan J. Gelenberg🇺🇸University of Arizona; University of Arizona College of Medicine- Phoenix
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Postpartum depression (PPD) affects 10-15% of mothers. Omega-3 fatty acids are an intriguing potential treatment for PPD.
Method
The efficacy of omega-3 fatty acids for PPD was assessed in an 8-week dose-ranging trial. Subjects were randomized to 0.5 g/day (n = 6), 1.4 g/day (n = 3), or 2.8 g/day (n = 7).
Results
Across groups, pretreatment Edinburgh Postnatal Depression Scale (EPDS) and Hamilton Rating Scale for Depression (HRSD) mean scores were 18.1 and 19.1 respectively; post-treatment mean scores were 9.3 and 10.0. Percent decreases on the EPDS and HRSD were 51.5% and 48.8%, respectively; changes from baseline were significant within each group and when combining groups. Groups did not significantly differ in pre- or post-test scores, or change in scores. The treatment was well tolerated.
Conclusion
This study was limited by small sample size and lack of placebo group. However, these results support further study of omega-3 fatty acids as a treatment for PPD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.