Low-density lipoprotein cholesterol and mortality in older people
Tikhonoff V, Casiglia E, Mazza A, Scarpa R, Thijs L, Pessina AC, Staessen JA
Journal of the American Geriatrics Society · 63 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2005-10-06 · J Am Geriatr Soc · vol. 53 · número 12 · págs. 2159–2164
- Editorial
- Wiley
- Citado
- 80 citas · más que el 93% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Cardiovascular Health and Risk Factors
- Palabras clave
- LDL cholesterol, mortality, older adults, cardiovascular mortality, heart failure, myocardial infarction, stroke mortality, J-shaped relationship, cardiovascular risk factors, sex differences
- MeSH
- humans, cardiovascular diseases, myocardial infarction, mortality, proportional hazards models, risk factors, prospective studies, aged, aged, 80 and over, italy, female, male, cholesterol, ldl, heart failure, stroke
7 autores
- Valérie Tikhonoff🇮🇹University of Padua
- Edoardo Casiglia🇮🇹🇧🇪University of Padua; KU Leuven
- Alberto Mazza🇮🇹🇧🇪University of Padua; KU Leuven
- Roberta Scarpa🇮🇹🇧🇪University of Padua; KU Leuven
- Lutgarde Thijs🇮🇹🇧🇪University of Padua; KU Leuven
- Achille Cesare Pessina🇮🇹🇧🇪University of Padua; KU Leuven
- Jan Albert Staessen🇮🇹🇧🇪University of Padua; KU Leuven
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To investigate the role of low-density lipoprotein cholesterol (LDL-C) as a predictor of mortality in elderly subjects.
Design
Population-based prospective cohort study.
Setting
Two communities in northern Italy.
Participants
Three thousand one hundred twenty Caucasian subjects aged 65 and older recruited in for the Cardiovascular Study in the Elderly and followed up for 12 years.
Measurements
Anthropometric measures: fasting plasma total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL-C, glucose, creatinine, and body mass index. Clinical measures: medical assessment, diabetes mellitus, hypertension, stroke, coronary disease, heart failure, and smoking and drinking habits. Vital status measures: death certificates from the Registry Office and causes of death according to the International Classification of Diseases. After plotting mortality rates using quartiles of LDL-C, relative hazard rates (RHRs) were calculated using multivariate Cox regression analyses. When the trend was nonlinear, the RHRs were further calculated for the 25th, 50th, and 75th percentiles of the distribution to confirm curvilinearity.
Results
The distribution of risk of total mortality in women and of fatal heart failure in all subjects was curvilinear (non J-shaped), decreasing nonlinearly with LDL-C. For total mortality in men and cardiovascular mortality in both sexes, the relationship with LDL-C was J-shaped. The risk of fatal myocardial infarction was J-shaped in men, whereas it increased linearly with higher LDL-C in women. In both sexes, the association between stroke mortality and LDL-C was not significant.
Conclusion
This study adds to the uncertainty of the role of elevated levels of LDL-C as a risk factor for mortality in old people.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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