Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma
Mickleborough TD, Lindley MR, Ionescu AA, Fly AD
Chest · 156 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-01-01 · Chest · vol. 129 · número 1 · págs. 39–49
- Editorial
- Elsevier BV
- Citado
- 251 citas · más que el 99% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Asthma and respiratory diseases · Fatty Acid Research and Health · Exercise and Physiological Responses
- Palabras clave
- fish oil supplementation, exercise-induced bronchoconstriction, asthma, eicosapentaenoic acid, docosahexaenoic acid, anti-inflammatory activity, leukotriene B4, leukotriene B5, induced sputum, inflammatory cytokines, leukotriene C4, prostaglandin D2, polymorphonuclear leukocytes
- MeSH
- sputum, humans, asthma, eicosapentaenoic acid, leukotriene b4, fish oils, exercise test, forced expiratory volume, leukocyte count, treatment outcome, follow-up studies, cross-over studies, double-blind method, bronchoconstriction, dietary supplements, adult, female, male
4 autores
- Timothy D. Mickleborough🇺🇸Indiana University Bloomington; Indiana University
- Martin R. Lindley🇺🇸Indiana University Bloomington; Indiana University
- Alina Ionescu🇬🇧University Hospital of Wales; University Hospital Llandough; University of Wales
- Alyce D. Fly🇺🇸Indiana University Bloomington; Indiana University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous research has demonstrated that fish oil supplementation has a protective effect on exercise-induced bronchoconstriction (EIB) in elite athletes, which may be attributed to its antiinflammatory properties. Since EIB in asthma involves proinflammatory mediator release, it is feasible that fish oil supplementation may reduce the severity of EIB in asthmatic subjects.
Study objectives
To determine the efficacy of fish oil supplementation on severity of EIB in subjects with asthma.
Design
Randomized, double-blind, crossover study.
Setting
Lung function and exercise testing in a university research laboratory.
Patients and measurements
Sixteen asthmatic patients with documented EIB entered the study on their normal diet and then received either fish oil capsules containing 3.2 g of eicosapentaenoic acid and 2.0 g of docohexaenoic acid (fish oil diet, n = 8) or placebo capsules (placebo diet, n = 8) daily for 3 weeks. At the beginning of the study (normal diet) and at the end of each treatment phase, the following pre-exercise and postexercise measures were assessed: (1) pulmonary function; (2) induced sputum differential cell count percentage and proinflammatory eicosanoid metabolite (leukotriene C4 [LTC4]-leukotriene E4 [LTE4] and prostaglandin D2 [PGD2]) and cytokine (interleukin [IL]-1beta and tumor necrosis factor [TNF]-alpha) concentrations; and (3) eicosanoid metabolites leukotriene B4 (LTB4) and leukotriene B5 (LTB(5)) generation from activated polymorphonuclear leukocytes (PMNLs).
Results
On the normal and placebo diet, subjects exhibited EIB. However, the fish oil diet improved pulmonary function to below the diagnostic EIB threshold, with a concurrent reduction in bronchodilator use. Induced sputum differential cell count percentage and concentrations of LTC4-LTE4, PGD2, IL-1beta, and TNF-alpha were significantly reduced before and following exercise on the fish oil diet compared to the normal and placebo diets. There was a significant reduction in LTB4 and a significant increase in LTB5 generation from activated PMNLs on the fish oil diet compared to the normal and placebo diets.
Conclusion
Our data suggest that fish oil supplementation may represent a potentially beneficial nonpharmacologic intervention for asthmatic subjects with EIB.
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