Intradialytic parenteral nutrition: comparison of olive oil versus soybean oil-based lipid emulsions
Cano NJ, Saingra Y, Dupuy AM, Lorec-Penet AM, Portugal H, Lairon D, Cristol JP, Come A, Le Brun A, Atlan P, Leverve XM
The British journal of nutrition · 34 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-01-01 · Br J Nutr · vol. 95 · número 1 · págs. 152–159
- Editorial
- Cambridge University Press
- Citado
- 51 citas · más que el 94% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Dialysis and Renal Disease Management · Central Venous Catheters and Hemodialysis
- Palabras clave
- intradialytic parenteral nutrition, olive oil, soybean oil, intravenous lipid emulsion, end-stage renal disease, nutritional status, plasma lipids, lipoproteins, oxidative stress, inflammation, immunological parameters, alpha-tocopherol, malondialdehyde, C-reactive protein, lipoprotein(a)
- MeSH
- humans, nutrition disorders, cholesterol, dietary fats, unsaturated, soybean oil, fat emulsions, intravenous, triglycerides, phospholipids, plant oils, parenteral nutrition, renal dialysis, prospective studies, double-blind method, oxidative stress, aged, female, male, olive oil
11 autores
- Noël Cano · autor de correspondencia
- Yannick Saingra
- Anne‐Marie Dupuy🇫🇷Hôpital Lapeyronie
- Anne‐Marie Lorec🇫🇷Hôpital Sainte-Marguerite
- Henri Portugal🇫🇷Hôpital Sainte-Marguerite
- Denis Lairon🇫🇷Inserm; Institut National de la Recherche Agronomique
- Jean‐Paul Cristol🇫🇷Hôpital Lapeyronie
- Adrien Come🇫🇷Baxter (France)
- Alexia Le Brun🇫🇷Baxter (France)
- Philippe Atlan🇫🇷Baxter (France)
- Xavier Maurice Leverve🇫🇷Inserm; Université Joseph Fourier; Laboratory of Fundamental and Applied Bioenergetics
Resumen
El texto original del estudio, en el idioma en que se publicó.
Lipid, oxidative and inflammatory parameters are frequently altered in dialysis patients and may be worsened by intravenous lipid emulsions (ILE). We assessed the efficacy and tolerance of olive as compared with standard soybean oil-based ILE during intradialytic parenteral nutrition (IDPN). IDPN mixtures containing amino acids, glucose, and either olive oil (OO group, n 17) or soybean oil-based ILE (SO group, n 18) were administered in a 5-week randomized, double-blind study. On days 0 and 35, patients' nutritional status was assessed by BMI, normalized protein catabolic rate, predialytic creatinine, serum albumin and transthyretin; lipid metabolism by plasma LDL- and HDL-cholesterol, triacylglycerols, phospholipids, apo A-I, A-II, B, C-II, C-III, E and lipoprotein (a); oxidative status by alpha-tocopherol, retinol, selenium, glutathione peroxidase, malondialdehyde and advanced oxidized protein products; inflammatory status by serum C-reactive protein, orosomucoid, IL-2 and IL-6. No serious adverse event was observed. Significant changes were observed from day 0 to day 35 (P<0.05): nutritional criteria improved (albumin in OO; albumin, transthyretin and creatinine in SO); LDL-cholesterol, apo B, C-II, C-III and apo A-I/A-II ratio increased in both groups. HDL-cholesterol decreased in OO; apo E increased and lipoprotein (a) decreased in SO; alpha-tocopherol/cholesterol ratio increased in OO; malondialdehyde decreased in both groups; IL-2 increased in both groups. The between-group comparison only showed the following differences: alpha-tocopherol/cholesterol increased in OO; lipoprotein (a) decreased in SO. From these data, it was concluded that OO- and SO-based IDPNs similarly improved nutritional status and influenced plasma lipid, oxidative, inflammatory and immune parameters.
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