Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men
Rees D, Miles EA, Banerjee T, Wells SJ, Roynette CE, Wahle KW, Calder PC
The American journal of clinical nutrition · 271 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-02-01 · Am J Clin Nutr · vol. 83 · número 2 · págs. 331–342
- Editorial
- Elsevier BV
- Citado
- 400 citas · más que el 99% de estudios similares · 14.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- eicosapentaenoic acid, omega-3 fatty acids, innate immunity, dose-response relationship, aging, phospholipid incorporation, mononuclear cells, neutrophil respiratory burst, monocyte phagocytosis, inflammatory cytokines, prostaglandin E2, dietary supplementation, healthy men
- MeSH
- neutrophils, leukocytes, mononuclear, humans, eicosapentaenoic acid, dinoprostone, phospholipids, cytokines, analysis of variance, double-blind method, respiratory burst, phagocytosis, aging, dose-response relationship, drug, dietary supplements, adolescent, adult, aged, middle aged, male, immunity, innate
7 autores
- Dinka Rees🇬🇧University of Aberdeen; University of Southampton; Robert Gordon University
- Elizabeth A. Miles🇬🇧 · autor de correspondenciaUniversity of Aberdeen; University of Southampton; Robert Gordon University
- Tapati Banerjee🇬🇧University of Aberdeen; University of Southampton; Robert Gordon University
- Solenne J. Wells🇬🇧University of Aberdeen; University of Southampton; Robert Gordon University
- Catherine E. Roynette🇬🇧University of Aberdeen; University of Southampton; Robert Gordon University
- Klaus W.J. Wahle🇬🇧University of Aberdeen; University of Southampton; Robert Gordon University
- Philip C. Calder🇬🇧University of Aberdeen; University of Southampton; Robert Gordon University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increasing intakes of long-chain n-3 polyunsaturated fatty acids (PUFAs) can decrease markers of immunity. However, dose- and age-related responses have not been identified.
Objective
The objective was to determine the effects of different amounts of eicosapentaenoic acid (EPA) on innate immune outcomes in young and older males.
Design
In a controlled, double-blind study, healthy young and older men consumed 1 of 4 supplements provided as capsules: placebo (corn oil) or different amounts of an oil providing 1.35, 2.7, or 4.05 g EPA/d for 12 wk. Blood samples were collected at baseline and after 12 wk.
Results
EPA was incorporated in a linear dose-response fashion into plasma and mononuclear cell (MNC) phospholipids; incorporation was greater in the older men. EPA treatment did not alter neutrophil or monocyte phagocytosis, monocyte respiratory burst, or the production of inflammatory cytokines by MNCs in the young or older men. EPA treatment caused a dose-dependent decrease in neutrophil respiratory burst only in the older men. Increased incorporation of EPA into plasma or MNC phospholipids was associated with decreased production of prostaglandin E2 by MNCs from both young and older men.
Conclusions
Older subjects incorporate EPA into plasma and MNC phospholipids more readily than do younger subjects. Other than prostaglandin E2 production, innate immune responses in young subjects are not affected by an EPA intake of < or =4.05 g/d. Older subjects are more sensitive to the immunologic effects of EPA, and the neutrophil respiratory burst is lower at higher EPA intakes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.