Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury
Singer P, Theilla M, Fisher H, Gibstein L, Grozovski E, Cohen J
Critical care medicine · 216 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-09 · Crit Care Med · vol. 34 · número 4 · págs. 1033–1038
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 394 citas · más que el 100% de estudios similares · 19.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Respiratory Support and Mechanisms · Nosocomial Infections in ICU
- Palabras clave
- acute lung injury, acute respiratory distress syndrome, enteral nutrition, eicosapentaenoic acid, gamma-linolenic acid, omega-3 fatty acids, antioxidants, mechanical ventilation, oxygenation, ventilator compliance, resting energy expenditure, mechanical ventilation duration, critically ill patients
- MeSH
- humans, eicosapentaenoic acid, gamma-linolenic acid, treatment outcome, respiration, artificial, enteral nutrition, prospective studies, adult, middle aged, female, male, respiratory distress syndrome
6 autores
- Pierre Singer🇮🇱Tel Aviv University; Rabin Medical Center
- M. Theilla🇮🇱Tel Aviv University; Rabin Medical Center
- Haran Fisher🇮🇱Tel Aviv University; Rabin Medical Center
- Lilly Gibstein🇮🇱Tel Aviv University; Rabin Medical Center
- Elad Grozovski🇮🇱Tel Aviv University; Rabin Medical Center
- Jonathan David Cohen🇮🇱Tel Aviv University; Rabin Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To explore the effects of an enteral diet enriched with eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and antioxidants on the respiratory profile and outcome of patients with acute lung injury.
Design
Single-center, prospective, randomized, controlled, unblinded study.
Setting
General intensive care department of a tertiary-care, university-affiliated hospital.
Patients
A total of 100 patients with acute lung injury, diagnosed according to the American-European Consensus Conference on ARDS.
Interventions
Patients were randomized to receive the standard isonitrogenous, isocaloric enteral diet or the standard diet supplemented with EPA and GLA for 14 days.
Measurements and main results
Patient demographics, Acute Physiology and Chronic Health Evaluation II score, and type of admission were noted at admission. Compared with baseline oxygenation (EPA + GLA group vs. control group), by days 4 and 7, patients receiving the EPA + GLA diet showed significant improvement in oxygenation (PaO(2)/FIO(2), 317.3 +/- 99.5 vs. 214.3 +/- 56.4 and 296.5 +/- 165.3 vs. 236.3 +/- 79.8, respectively; p < .05). Compliance was significantly higher in the EPA + GLA group observed at day 7 (55.1 +/- 46.5 vs. 35.2 +/- 20.0 mL/mbar, p < .05). No significant difference was found in nutritional variables. Resting energy expenditure was significantly higher in patients in the EPA + GLA group, but their body mass index was also higher (p < .05). A significant difference was found in length of ventilation (p < .04) in favor of the EPA + GLA group. There was no between-group difference in survival.
Conclusions
In patients with acute lung injury, a diet enriched with EPA + GLA may be beneficial for gas exchange, respiratory dynamics, and requirements for mechanical ventilation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.