Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial
Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B
Archives of internal medicine · 163 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (AG-10353)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2006-02-27 · Arch Intern Med · vol. 166 · número 4 · pág. 424
- Editorial
- American Medical Association
- Citado
- 246 citas · más que el 100% de estudios similares · 18.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D3, vitamin D supplementation, calcium citrate malate, falls, fall prevention, older adults, sex differences, physical activity, 25-hydroxyvitamin D
- MeSH
- humans, calcium, cholecalciferol, vitamins, drug therapy, combination, risk factors, follow-up studies, accidental falls, time factors, aged, female, male
3 autores
- Heike Annette Bischoff-Ferrari🇨🇭University of Zurich; University Hospital Zurich
- Endel John Orav🇺🇸🇨🇭Tufts University; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
- Bess Dawson‐Hughes🇺🇸🇨🇭Tufts University; Harvard University; University of Zurich; University Hospital Zurich; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A recent meta-analysis found that cholecalciferol (vitamin D) should reduce falls by more than 20%. However, little is known about whether supplemental cholecalciferol plus calcium citrate malate will lower the long-term risk of falling in men, active older individuals, and older individuals with higher 25-hydroxyvitamin D levels.
Methods
We studied the effect of 3-year supplementation with cholecalciferol-calcium on the risk of falling at least once in 199 men and 246 women 65 years or older and living at home. Individuals received 700 IU of cholecalciferol plus 500 mg of calcium citrate malate per day or placebo in a randomized double-blind manner. Subjects were classified as less physically active if physical activity was below the median level. Low 25-hydroxyvitamin D levels were classified as those below 32 ng/mL (<80 nmol/L).
Results
In 3 years, 55% of women and 45% of men reported at least 1 fall. Mean +/- SD baseline 25-hydroxyvitamin D levels were 26.6 +/- 12.7 ng/mL (66.4 +/- 31.7 nmol/L) in women and 33.2 +/- 14.2 ng/mL (82.9 +/- 34.9) in men. Cholecalciferol-calcium significantly reduced the odds of falling in women (odds ratio [OR], 0.54; 95% confidence interval [CI], 0.30-0.97), but not in men (OR, 0.93; 95% CI, 0.50-1.72). Fall reduction was most pronounced in less active women (OR, 0.35; 95% CI, 0.15-0.81). Baseline 25-hydroxyvitamin D level did not modulate the treatment effect.
Conclusions
Long-term dietary cholecalciferol-calcium supplementation reduces the odds of falling in ambulatory older women by 46%, and especially in less active women by 65%. Supplementation had a neutral effect in men independent of their physical activity level.
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