Salivary IgA responses to prolonged intensive exercise following caffeine ingestion
Bishop NC, Walker GJ, Scanlon GA, Richards S, Rogers E
Medicine and science in sports and exercise · 34 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-01 · Med Sci Sports Exerc · vol. 38 · número 3 · págs. 513–519
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 65 citas · más que el 92% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- De pago
- Áreas de investigación
- Exercise and Physiological Responses · Coffee research and impacts · Sports Performance and Training
- Palabras clave
- salivary IgA, caffeine ingestion, prolonged exercise, endurance cycling, sympathetic activation, epinephrine, alpha-amylase, salivary flow rate, autonomic nervous system, exercise immunology
- MeSH
- saliva, humans, caffeine, immunoglobulin a, placebos, exercise, cross-over studies, bicycling, adult, male
5 autores
- NICOLETTE CLAIRE BISHOP🇬🇧Loughborough University
- Gary J. Walker🇬🇧Loughborough University
- GABRIELLA A. SCANLON🇬🇧Loughborough University
- STEPHEN RICHARDS🇬🇧Loughborough University
- ELEANOR ROGERS🇬🇧Loughborough University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Prolonged, intensive exercise is associated with a reduction in concentration and secretion of salivary IgA (s-IgA). Saliva composition and secretion are under autonomic nervous system control, and caffeine ingestion, a widespread practice among athletes for its ergogenic properties, is associated with increased sympathetic nervous system activation. Therefore, this study investigated the influence of caffeine ingestion on s-IgA responses to prolonged, intensive exercise.
Methods
In a randomized crossover design, 11 endurance-trained males cycled for 90 min at 70% VO2peak on two occasions, having ingested 6 mg x kg(-1) body mass of caffeine (CAF) or placebo (PLA) 1 h before exercise. Whole, unstimulated saliva samples were collected before treatment (baseline), preexercise, after 45 min of exercise (midexercise), immediately postexercise, and 1 h postexercise. Venous blood samples were collected from a subset of six of these subjects at baseline, preexercise, postexercise, and 1 h postexercise.
Results
An initial pilot study found that caffeine ingestion had no effect on s-IgA concentration, secretion rate, or saliva flow rate at rest. Serum caffeine concentration was higher on CAF than PLA at preexercise, postexercise, and 1 h postexercise (P < 0.001). Plasma epinephrine concentration was higher on CAF than PLA at pre- and postexercise (P < 0.05). s-IgA concentration was higher on CAF than PLA at mid- and postexercise (P < 0.01), and s-IgA secretion rate was higher on CAF than PLA at midexercise only (P < 0.02). Caffeine ingestion did not affect saliva flow rate. Saliva alpha-amylase activity and secretion rate were higher on CAF than PLA (main effect for trial, P < 0.05).
Conclusions
These findings suggest that caffeine ingestion before intensive exercise is associated with elevated s-IgA responses during exercise, which may be related to increases in sympathetic activation.
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