Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users
Childs E, de Wit H
Psychopharmacology · 139 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- National Center for Research Resources
- Gobierno
- NIH Clinical Center
- Gobierno
- NIDA NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01-RR 00055); National Institute on Drug Abuse (DA 02812)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2006-03-15 · Psychopharmacology (Berl) · vol. 185 · número 4 · págs. 514–23
- Editorial
- Springer Science+Business Media
- Citado
- 218 citas · más que el 95% de estudios similares · 4.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Neurotransmitter Receptor Influence on Behavior
- Palabras clave
- caffeine, acute caffeine effects, psychostimulant effects, subjective effects, blood pressure, arousal, mood, sustained attention, short-term memory, psychomotor performance, behavioral inhibition, caffeine withdrawal, caffeine tolerance
- MeSH
- saliva, humans, substance-related disorders, dextroamphetamine, caffeine, central nervous system stimulants, double-blind method, behavior, affect, memory, short-term, psychomotor performance, arousal, reaction time, dose-response relationship, drug, adolescent, adult, female, male, surveys and questionnaires
2 autores
- Emma Childs🇺🇸University of Chicago
- Harriet de Wit🇺🇸 · autor de correspondenciaUniversity of Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Caffeine produces mild psychostimulant effects that are thought to underlie its widespread use. However, the direct effects of caffeine are difficult to evaluate in regular users of caffeine because of tolerance and withdrawal. Indeed, some researchers hypothesize that the psychostimulant effects of caffeine are due largely to the reversal of withdrawal and question whether there are direct effects of caffeine consumption upon mood, alertness, or mental performance in nondependent individuals.
Objective
This study investigated the physiological, subjective, and behavioral effects of 0, 50, 150, and 450 mg caffeine in 102 light, nondependent caffeine users.
Methods
Using a within-subjects design, subjects participated in four experimental sessions, in which they received each of the four drug conditions in random order under double blind conditions. Participants completed subjective effects questionnaires and vital signs were measured before and at repeated time points after drug administration. Forty minutes after the capsules were ingested, subjects completed behavioral tasks that included tests of sustained attention, short-term memory, psychomotor performance, and behavioral inhibition.
Results
Caffeine significantly increased blood pressure, and produced feelings of arousal, positive mood, and high. Caffeine increased the number of hits and decreased reaction times in a vigilance task, but impaired performance on a memory task.
Conclusion
We confirm that acute doses of caffeine, at levels typically found in a cup of coffee, produce stimulant-like subjective effects and enhance performance in light, nondependent caffeine users. These findings support the idea that the drug has psychoactive effects even in the absence of withdrawal.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.