Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial
Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL
International journal of obesity (2005) · 56 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-21 · Int J Obes (Lond) · vol. 30 · número 10 · págs. 1545–1556
- Editorial
- Springer Nature
- Citado
- 93 citas · más que el 79% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Pharmacology and Obesity Treatment · Coffee research and impacts · Regulation of Appetite and Obesity
- Palabras clave
- Ephedra, caffeine, dietary supplements, weight loss, obesity, premenopausal women, body composition, fat mass, insulin sensitivity, leptin, adiponectin, ghrelin, lipid profile, cholesterol, triglycerides, supplement safety, quality of life
- MeSH
- humans, ephedra, obesity, body weight, weight loss, caffeine, insulin, blood glucose, lipids, plant extracts, electrocardiography, body mass index, treatment outcome, phytotherapy, risk factors, double-blind method, body composition, blood pressure, heart rate, quality of life, dietary supplements, adult, middle aged, patient dropouts, female
9 autores
- Robert M. Hackman🇺🇸 · autor de correspondenciaUniversity of California, Davis
- Peter Joseph Havel🇺🇸University of California, Davis
- H J Schwartz🇺🇸University of California, Davis
- John C. Rutledge🇺🇸University of California, Davis
- Mitchell Watnik🇺🇸California State University, East Bay
- Elizabeth M. Noceti🇺🇸University of California, Davis
- Sidney J. Stohs🇺🇸Creighton University
- Judith S. Stern🇺🇸University of California, Davis
- Carl L. Keen🇺🇸University of California, Davis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the safety and efficacy of a dietary supplement with a low dose of ephedra and caffeine in overweight/obese premenopausal female subjects.
Design
A 9-month, double-blind, randomized control study compared the efficacy and safety of a dietary supplement with ephedra and caffeine to a control supplement.
Subjects
Sixty-one healthy, premenopausal women with body mass index (BMI) from 27 to 39 kg/m2 were randomly assigned and received a dietary supplement (40 mg/day ephedra alkaloids, 100 mg/day caffeine, high potency mixture of vitamins, minerals, omega-3 fatty acids) or a control supplement for 9 months.
Efficacy
changes in body weight, body composition, lipids, insulin, leptin, adiponectin, ghrelin, and self-reports of physical activity, diet and quality of life indices.
Safety
blood pressure, heart rate, electrocardiograms, urinalysis, blood histology, serum chemistry measures and self-reported symptoms.
Results
Forty-one women completed the study. The treatment group lost significantly more body weight (-7.18 kg) and body fat (-5.33 kg) than the control group (-2.25 and -0.99 kg, respectively), and showed significant declines in heart rate, serum cholesterol, triglycerides, cholesterol to high-density lipoprotein ratio, glucose, fasting insulin, and leptin. Blood pressure, electrocardiograms, other clinical chemistry measures, blood histology, urinalysis, and self-reported physical activity were similar in the groups. Minor symptoms included dry mouth, insomnia, nervousness and palpitations. The treatment group reported more energy and decreased appetite compared to controls and scored higher on a quality of life domain assessing vitality.
Conclusion
A dietary supplement containing a low potency ephedra/caffeine mixture appeared safe and effective in causing loss of weight and body fat, and improving several metabolic parameters, including insulin sensitivity and lipid profiles when tested under physician supervision. Such supplements could be a useful tool to assist with weight loss.
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