Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals
Mølvig J, Pociot F, Worsaae H, Wogensen LD, Baek L, Christensen P, Mandrup-Poulsen T, Andersen K, Madsen P, Dyerberg J
Scandinavian journal of immunology · 78 citas
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- Financiación no declarada
Publicación
- Publicado
- 1991-10-01 · Scand J Immunol · vol. 34 · número 4 · págs. 399–410
- Editorial
- Wiley
- Citado
- 112 citas · más que el 77% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Inflammatory mediators and NSAID effects · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 polyunsaturated fatty acids, dietary supplementation, type 1 diabetes, mononuclear cell proliferation, IL-1β, TNF-α, prostaglandin E2, leukotriene B4, arachidonic acid metabolites, eicosapentaenoic acid, monocytes, platelets
- MeSH
- leukocytes, mononuclear, monocytes, humans, diabetes mellitus, type 1, phenylenediamines, lipopolysaccharides, blood glucose, fatty acids, unsaturated, leukotriene b4, dinoprostone, tumor necrosis factor-alpha, phytohemagglutinins, interleukin-1, monokines, leukocyte count, blood sedimentation, cell division, dose-response relationship, drug, adult, male
11 autores
- Jens Mølvig · autor de correspondencia
- Flemming Pociot
- Helle Worsaae
- Lise Wogensen
- Leif Bæk🇩🇰Copenhagen University Hospital
- Peter Seier Christensen🇩🇰University of Copenhagen
- Thomas R Mandrup-Poulsen
- K. ANDERSEN🇩🇰Herlev Hospital
- Peter Madsen🇩🇰Aalborg University Hospital
- J. Dyerberg🇩🇰Aalborg University Hospital
- Jørn Nerup
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effects of dietary supplementation with omega-3-polyunsaturated fatty acids (omega-3-PUFA) on the proliferative response of PBMC and on the secretion of monokines and arachidonic acid metabolites from PBMC and monocytes (Mo) from healthy subjects and patients with recent-onset insulin-dependent diabetes mellitus (IDDM) were examined. Three groups of eight to nine healthy individuals were randomized to either 2.0 g/day or 4.0 g/day of omega-3-PUFA devoid of vitamins A and D, or an isocaloric amount of placebo. Furthermore, eight patients with recent-onset IDDM received 4.0 g/day of omega-3-PUFA. IL-1 beta production and TNF-alpha secretion was determined before and after 7 weeks of treatment, and 10 weeks after withdrawal of treatment. Significant increases in platelet and PBMC membrane eicosapentaenoic acid was found in omega-3-PUFA-treated individuals. omega-3-PUFA treatment significantly reduced the content of IL-1 beta in lysates of PBMC, but did not affect PBMC or Mo secretion of IL-1 beta, TNF-alpha or prostaglandin E2 (PGE2) or PBMC leukotriene B4 (LTB4) secretion in healthy subjects or in IDDM patients. A significant inhibition of the PHA-stimulated, but not the spontaneous or PPD-stimulated, proliferative response of PBMC was observed in healthy and diabetic subjects treated with omega-3-PUFA. No correlation was found between PHA-stimulated PBMC proliferation and PBMC secretion of TNF-alpha and IL-1 beta. There were no significant differences in the spontaneous or the PPD- or PHA-stimulated proliferative responses of PBMC between diabetic and healthy individuals at entry. We conclude that although dietary supplementation with 4.0 g/day of omega-3-PUFA inhibits the proliferation of PBMC and reduces IL-1 beta immunoreactivity in PBMC and Mo, it does not alter monokine, PGE2 or LTB4, secretion in healthy or IDDM subjects.
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