Maternal exposure to caffeine and risk of congenital anomalies: a systematic review
Browne ML
Epidemiology (Cambridge, Mass.) · 46 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Public Health Service
- Gobierno
- PHS HHS
- Subvenciones
- U.S. Public Health Service (U50/CCU223184)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2006-03-28 · Epidemiology · vol. 17 · número 3 · págs. 324–331
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 81 citas · más que el 93% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Prenatal Substance Exposure Effects · Pharmacological Effects and Toxicity Studies
- Palabras clave
- maternal caffeine consumption, congenital malformations, teratogenicity, coffee, tea, orofacial clefts, cardiovascular anomalies, prenatal exposure, major malformations
- MeSH
- humans, caffeine, teratogens, risk assessment, pregnancy, adolescent, adult, female, congenital abnormalities
1 autor
- Marilyn L. Browne🇺🇸🇰🇪 · autor de correspondenciaNew York State Department of Health; Centers for Disease Control and Prevention
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caffeine is teratogenic in animal studies when administered at high concentrations. Previous review articles have concluded that maternal caffeine consumption does not influence the risk of congenital anomalies. These reviews were narrative rather than systematic. The objective of the current systematic review is to provide a critical appraisal of epidemiologic evidence.
Methods
A search of the MEDLINE/PUBMED database (1966-October 2004) was conducted for all published epidemiologic studies with maternal intake of caffeine as an exposure and major malformations as an outcome. Study characteristics were abstracted, internal validity evaluated, and study findings summarized.
Results
Twenty-five papers met the initial criteria for inclusion, of which 18 were subsequently excluded as a result of other limitations. Effect estimates for the remaining 7 studies were generally close to null. Specific subgroup analyses were summarized across studies (associations between coffee and cardiovascular malformations, coffee and oral clefts, and tea and cardiovascular malformations). Summary point estimates ranged from 1.0 to 1.2; the upper limits of all confidence intervals were less than 1.7.
Conclusions
There is no evidence to support a teratogenic effect of caffeine in humans. Current epidemiologic evidence is not adequate to assess the possibility of a small change in risk of congenital anomalies resulting from maternal caffeine consumption.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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