Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects
Klass DM, Bührmann K, Sauter G, Del Puppo M, Scheibner J, Fuchs M, Stange EF
Alimentary pharmacology & therapeutics · 17 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-17 · Aliment Pharmacol Ther · vol. 23 · número 7 · págs. 895–905
- Editorial
- Wiley
- Citado
- 23 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cholesterol and Lipid Metabolism · Gallbladder and Bile Duct Disorders · Lipid metabolism and disorders
- Palabras clave
- dietary cholesterol, obesity, hepatic cholesterol synthesis, biliary cholesterol secretion, bile acid synthesis, cholesterol saturation index, cholesterol gallstone formation, mass isotopomer distribution analysis, 7α-hydroxy-4-cholesten-3-one, 27-hydroxycholesterol
- MeSH
- gallbladder, bile, humans, obesity, bile acids and salts, cholestenones, cholesterol, hydroxycholesterols, lipids, cholesterol, dietary, cross-over studies, double-blind method, energy intake, adult, female, male
7 autores
- Dietmar M. Klass🇩🇪University Hospital Schleswig-Holstein; University Hospital Ulm; University of Lübeck
- K. BÜHRMANN🇩🇪University Hospital Schleswig-Holstein; University of Lübeck
- Gerd H. Sauter
- Marina Del Puppo🇮🇹University of Milano-Bicocca
- J Scheibner🇩🇪University Hospital Schleswig-Holstein; University of Lübeck
- Michael A. Fuchs🇩🇪University Hospital Schleswig-Holstein; University Hospital Ulm; University of Lübeck
- Eduard Friedrich Stange🇩🇪 · autor de correspondenciaRobert Bosch Hospital; University Hospital Schleswig-Holstein; University of Lübeck
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increased biliary cholesterol secretion together with elevated cholesterol synthesis may predispose obese subjects to cholesterol gallstone formation.
Aim
To investigate whether processing of dietary cholesterol is altered in obesity, we enrolled eight lean and seven obese subjects in a double-blind crossover study.
Methods
Cholesterol consumption was 300 mg/day on low and 1300 mg/day on high cholesterol diet. After 3 weeks on either diet, hepatic bile was collected to determine biliary lipid secretion, and bile salt composition by high-performance liquid chromatography and cholesterol saturation index was calculated. Cholesterol synthesis was measured employing mass isotopomer distribution analysis. Bile acid synthesis via neutral and acidic pathway was assessed by serum levels of 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol.
Results
Cholesterol synthesis was increased in obese compared with lean and feedback inhibited only in obese. On low cholesterol diet, cholesterol secretion was doubled in obese but bile acid composition and synthesis was similar between the two groups. After high cholesterol diet, cholesterol saturation index and bile secretion were unchanged. In contrast to obese, lean increased bile acid synthesis only via the acidic pathway.
Conclusions
Dietary cholesterol appears to preferentially induce bile acid synthesis via the acidic pathway in lean, whereas cholesterol synthesis was inhibited in obese. Thus, stable cholesterol saturation index may be achieved by different mechanisms.
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