Creatine supplementation improves muscle strength in patients with congestive heart failure
Kuethe F, Krack A, Richartz BM, Figulla HR
Die Pharmazie · 34 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-01 · Pharmazie · vol. 61 · número 3 · págs. 218–22
- Editorial
- National Institutes of Health
- Citado
- 52 citas · más que el 76% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Heart Failure Treatment and Management · Cardiovascular and exercise physiology
- Palabras clave
- creatine supplementation, congestive heart failure, muscle strength, peak oxygen uptake, anaerobic threshold, 6-minute walk test, quality of life, body weight, exercise capacity
- MeSH
- elbow, muscle, skeletal, humans, creatine, ultrasonography, walking, cross-over studies, double-blind method, oxygen consumption, quality of life, physical fitness, dietary supplements, aged, female, male, heart failure, surveys and questionnaires
4 autores
- Friedhelm Kuethe🇩🇪Friedrich Schiller University Jena
- Andreas Krack
- Barbara Maria Richartz
- Hans Reiner Figulla
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Both, cardiac and skeletal muscle creatine levels are depressed in patients with congestive heart failure (CHF). Oral supplementation of creatine (Cr) could increase physical performance in healthy volunteers. We therefore hypothesized that oral creatine supplementation improves skeletal muscle strength, quality of live and symptom-limited performance in patients with CHF.
Methods
In a double-blind, placebo-controlled and crossover-designed study, 20 patients suffering from congestive heart failure more than 6 months and a peak oxygen uptake (peak VO2) below 20 ml/min/kg received 4 x 5 g Cr daily vs. placebo for 6 weeks and were crossed over for the following 6 weeks. Peak VO2, VO2 at the anaerobic threshold (VO2AT), ejection fraction (EF), distance in 6-minute-walk-test (6 min W), and muscle strength (Modified Sphygmomanometer (MS)) were determined at baseline, after 6, and after 12 weeks. Dyspnoea after 6-minute-walk-test was measured using the Borg Scale. Quality of live was assessed with the Minnesota Living with Heart Failure Questionnaire (MLHFQ).
Results
13 of 20 Patients finished the study. After 6 weeks of creatine supplementation there was a significant increase in body weight and muscle strength compared to baseline and placebo (p < 0.05). However, there was no significant change in peak VO2, VO2AT, walking distance, quality of life assessment and EF.
Conclusion
Short-term creatine supplementation inaddition to standard medication in patients with CHF leads to an increase in body weight and an improvement of muscle strength. This effect is restricted to the time of supplementation.
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