The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs
Herron KL, McGrane MM, Waters D, Lofgren IE, Clark RM, Ordovas JM, Fernandez ML
The Journal of nutrition · 68 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Subvenciones
- U.S. Department of Agriculture (53‐K06‐5‐10)
Según 1 financiador declarado.
Publicación
- Publicado
- 2006-05-01 · J Nutr · vol. 136 · número 5 · págs. 1161–1165
- Editorial
- Elsevier BV
- Citado
- 108 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition, Genetics, and Disease · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- dietary cholesterol, carotenoids, lutein, zeaxanthin, egg consumption, LDL cholesterol, serum cholesterol, genetic variation, dietary response, plasma carotenoids
- MeSH
- humans, carotenoids, lutein, cholesterol, dietary, lipoproteins, atp-binding cassette transporters, dna, genotype, heterozygote, homozygote, polymorphism, genetic, eggs, adult, female, male, atp binding cassette transporter, subfamily g, member 5
7 autores
- Kristin L. Herron🇺🇸University of Connecticut
- Mary M. McGrane🇺🇸University of Connecticut
- David D. Waters🇺🇸University of Connecticut
- Ingrid Elizabeth Lofgren🇺🇸University of Connecticut
- Richard M. Clark🇺🇸University of Connecticut
- José María Ordovás🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- María Luz Fernández🇺🇸 · autor de correspondenciaUniversity of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
The ATP binding cassette G5 (ABCG5) polymorphisms have been postulated to play a role in the response to dietary cholesterol. The objective of this study was to examine the contribution of the ABCG5 polymorphism on the plasma response to consumption of cholesterol and carotenoids from eggs. For this purpose, genotyping was conducted for 40 men and 51 premenopausal women who were randomly assigned to consume an egg (EGG, 640 mg/d additional dietary cholesterol and 600 microg lutein+ zeaxanthin) or placebo (SUB, 0 mg/d cholesterol, 0 microg lutein + zeaxanthin) diet for 30 d. The two arms of the dietary intervention were separated by a 3-wk washout period. Plasma concentrations of total cholesterol, LDL cholesterol (LDL-C), and HDL cholesterol were determined. Because eggs are an excellent source of lutein and zeaxanthin, the plasma levels of these carotenoids were also measured in a subset of subjects to determine whether the response to carotenoid intake was similar to that seen for dietary cholesterol and to evaluate the contribution of ABCG5 polymorphism to both responses. Individuals possessing the C/C genotype experienced a greater increase in both LDL-C (P < 0.05) and a trend for lutein (P = 0.08) during the EGG period compared with those individuals with the C/G (heterozygote) or G/G genotypes (homozygotes). These results, although obtained from a small number of subjects, suggest that the ABCG5 polymorphism may play a role in the plasma response to dietary cholesterol and carotenoids.
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