Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions
O'Keefe JH, Abuissa H, Sastre A, Steinhaus DM, Harris WS
The American journal of cardiology · 130 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-04 · Am J Cardiol · vol. 97 · número 8 · págs. 1127–1130
- Editorial
- Elsevier BV
- Citado
- 207 citas · más que el 99% de estudios similares · 13.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 22 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Heart Rate Variability and Autonomic Control · Cardiac Health and Mental Health
- Palabras clave
- omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, myocardial infarction, heart rate variability, resting heart rate, parasympathetic activity, sudden cardiac death, coronary artery disease, ejection fraction, arterial compliance, blood pressure, lipids, inflammatory markers
- MeSH
- humans, myocardial infarction, docosahexaenoic acids, eicosapentaenoic acid, cardiotonic agents, drug combinations, stroke volume, electrocardiography, ambulatory, exercise test, cross-over studies, double-blind method, recovery of function, heart rate, rest, dietary supplements, aged, male
5 autores
- James Henry O’Keefe🇺🇸Saint Luke's Hospital
- Hussam S. Abuissa🇺🇸University of Missouri–Kansas City
- Antonio Sastre🇺🇸MRIGlobal
- David M. Steinhaus🇺🇸University of Missouri–Kansas City
- William Stephen Harris🇺🇸University of Missouri–Kansas City
Resumen
El texto original del estudio, en el idioma en que se publicó.
We explored possible mechanisms by which recommended intakes of omega-3 fatty acids may decrease the risk for sudden cardiac death in patients with documented coronary heart disease. The cardioprotective effects of omega-3 fatty acids have been documented in epidemiologic and randomized controlled trials. These fatty acids are presumed to decrease susceptibility to fatal arrhythmias, but whether this is mediated by classic risk factors or direct cardiac mechanisms is not known. Eighteen white men with a history of myocardial infarction and ejection fractions <40% were randomized to placebo or omega-3 fatty acids (585 mg of docosahexaenoic acid and 225 mg of eicosapentaenoic acid) for two 4-month periods in a crossover design. At the end of each period, heart rate (HR), HR variability, and rate of HR recovery after exercise were determined, as were effects on arterial compliance, blood pressure, cardiac function, and fasting serum levels of lipids and inflammatory markers. Omega-3 fatty acids decreased HR at rest from 73 +/- 13 to 68 +/- 13 beats/min (p <0.0001) and improved 1-minute HR recovery after exercise (-27 +/- 10 to -32 +/- 12 beats/min, p <0.01). HR variability in the high-frequency band increased (p <0.02), but no change was noted in overall HR variability. There were no significant effects on blood pressure, arterial compliance, lipids, or inflammatory markers. These changes are consistent with an increase in vagal activity and may in part explain the observed decrease in risk for sudden cardiac death seen with omega-3 fatty acid supplementation.
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