An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence
McBride BF, Min B, Kluger J, Guertin D, Henyan NN, Coleman CI, Silver BB, White CM
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 16 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-03-28 · Ann Noninvasive Electrocardiol · vol. 11 · número 2 · págs. 163–169
- Editorial
- Wiley
- Citado
- 20 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 16 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Magnesium in Health and Disease · Cardiac electrophysiology and arrhythmias · Cardiac Arrhythmias and Treatments
- Palabras clave
- QTc interval, sotalol, dofetilide, antiarrhythmic drugs, atrial tachyarrhythmia, ventricular tachyarrhythmia, arrhythmia recurrence prevention, magnesium supplementation
- MeSH
- humans, recurrence, magnesium compounds, sotalol, sulfonamides, phenethylamines, lactic acid, anti-arrhythmia agents, electrocardiography, treatment outcome, drug therapy, combination, administration, oral, chi-square distribution, statistics, nonparametric, double-blind method, aged, female, male, arrhythmias, cardiac
8 autores
- Brian F. McBride🇺🇸Hartford Hospital; University of Connecticut
- Bokyung Min🇺🇸Hartford Hospital; University of Connecticut
- Jeffrey Kluger🇺🇸University of Connecticut; UConn Health
- Danette C. Guertin
- Nickole N. Henyan🇺🇸Hartford Hospital; University of Connecticut
- Craig Ian Coleman🇺🇸Hartford Hospital; University of Connecticut
- Burton B. Silver
- Charles Michael White🇺🇸Hartford Hospital; University of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intravenous magnesium reduces the QTc interval of patients receiving ibutilide. Whether oral magnesium can reduce the QTc interval associated with oral sotalol and dofetilide is not known. This study was undertaken to evaluate the impact of oral magnesium on the QTc interval and whether an inherent intracellular magnesium deficiency exists among patients with arrhythmias.
Methods
Participants receiving sotalol or dofetilide for atrial or ventricular arrhythmias were randomized to receive magnesium l-lactate (504 mg elemental magnesium daily, Niche Pharmaceuticals, Roanoke, TX) or placebo for 48 hours. A 12-lead electrocardiogram (ECG) was obtained at baseline, 3 hours, and 51 hours after dosing to correspond to the Tmax after oral ingestion. The QTc interval was measured from the ECGs and compared between groups. Intracellular magnesium concentrations were determined by energy-dispersive x-ray analysis at baseline and 51 hours after dosing (Intracellular Diagnostics, Inc., Foster City, CA).
Results
The QTc interval reductions from baseline were greater in the magnesium group than placebo at 3 and 51 hours (P = 0.015 and P < 0.001, respectively). Sixty-three percent of patients (regardless of experimental group) had baseline intracellular magnesium concentrations below the normal reference range of 33.9-41.9 mEq/IU, with an average level of 32.6 +/- 2.2 mEq/IU.
Conclusions
Oral magnesium l-lactate raises intracellular magnesium concentrations and lowers the QTc interval of patients receiving sotalol or dofetilide.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.