Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women
Lovallo WR, Farag NH, Vincent AS, Thomas TL, Wilson MF
Pharmacology, biochemistry, and behavior · 123 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-32050-S2); National Heart, Lung, and Blood Institute (HL32050); National Center for Research Resources (M01RR014467); National Center for Research Resources (RR 14467); National Heart, Lung, and Blood Institute (R01HL032050)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2006-03-01 · Pharmacol Biochem Behav · vol. 83 · número 3 · págs. 441–447
- Editorial
- Elsevier BV
- Citado
- 197 citas · más que el 89% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Coffee research and impacts · Stress Responses and Cortisol · Adrenal Hormones and Disorders
- Palabras clave
- cortisol, caffeine, psychological stress, physical activity, sex differences, stress response, hypothalamic-pituitary-adrenal axis, central nervous system stimulation
- MeSH
- saliva, humans, caffeine, hydrocortisone, exercise, cross-over studies, double-blind method, stress, psychological, sex characteristics, eating, adult, female, male
5 autores
- William R. Lovallo🇺🇸 · autor de correspondenciaOklahoma City VA Medical Center; University of Oklahoma Health Sciences Center
- Noha H. Farag🇺🇸University of Oklahoma Health Sciences Center
- Andrea S. Vincent🇺🇸University of Oklahoma
- Terrie L. Thomas🇺🇸University of Oklahoma Health Sciences Center
- Michael F. Wilson🇺🇸Kaleida Health; University at Buffalo, State University of New York
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine elevates cortisol secretion, and caffeine is often consumed in conjunction with exercise or mental stress. The interactions of caffeine and stress on cortisol secretion have not been explored adequately in women. We measured cortisol levels at eight times on days when healthy men and women consumed caffeine (250 mg x 3) and underwent either mental stress or dynamic exercise protocols, followed by a midday meal, in a double blind, placebo-controlled, crossover design. Men and women had similar cortisol levels at the predrug baselines, but they responded differently to mental stress and exercise. The cortisol response to mental stress was smaller in women than in men (p=.003). Caffeine acted in concert with mental stress to further increase cortisol levels (p=.011), the effect was similar in men and women. Exercise alone did not increase cortisol, but caffeine taken before exercise elevated cortisol in both men and women (ps<.05). After a postexercise meal, the women had a larger cortisol response than the men, and this effect was greater after caffeine (p<.01). Cortisol release in response to stress and caffeine therefore appears to be a function of the type of stressor and the sex of the subject. However, repeated caffeine doses increased cortisol levels across the test day without regard to the sex of the subject or type of stressor employed (p<.00001). Caffeine may elevate cortisol by stimulating the central nervous system in men but may interact with peripheral metabolic mechanisms in women.
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