Vitamin D supplementation and the prevention of fractures and falls: results of a randomised trial in elderly people in residential accommodation
Law M, Withers H, Morris J, Anderson F
Age and ageing · 121 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-04-26 · Age Ageing · vol. 35 · número 5 · págs. 482–486
- Editorial
- Oxford University Press
- Citado
- 191 citas · más que el 99% de estudios similares · 10.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Geriatric Care and Nursing Homes
- Palabras clave
- vitamin D supplementation, vitamin D2, fracture prevention, falls, hip fracture, non-vertebral fractures, older adults, care homes, residential care, nursing homes, serum 25-hydroxyvitamin D
- MeSH
- humans, phosphates, calcium, ergocalciferols, parathyroid hormone, vitamins, vitamin d, treatment outcome, accidental falls, aged, 80 and over, homes for the aged, female, male, bone density conservation agents, fractures, bone
4 autores
- Malcolm Law🇬🇧 · autor de correspondenciaQueen Mary University of London
- Heather Withers🇬🇧Queen Mary University of London
- Joan K. Morris🇬🇧Queen Mary University of London
- Frazer H. Anderson🇬🇧University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To determine whether vitamin D supplementation reduces the risk of fracture or falls in elderly people in care home accommodation.
Design
A randomised controlled trial of cluster design.
Setting and subjects
223 Residential units (mainly identical 30-bedded units), within 118 homes for elderly people throughout Britain, with 3,717 participating residents (76% women, average age 85 years). The units provided mainly or entirely residential care (35% of residents), nursing care (42%) or care for elderly mentally infirm (EMI) residents (23%).
Methods
Participants were randomly allocated by residential unit (cluster design) to a treated group offered ergocalciferol 2.5 mg every 3 months (equivalent to a daily dose of 1,100 IU), or to a control group. Fractures were reported by staff and confirmed in hospital, and routinely collected data on reported falls were obtained.
Results
After median follow-up of 10 months (interquartile range 7-14 months), 64 (3.6%) of 1,762 vitamin D-treated residents and 51 (2.6%) of 1,955 controls had one or more non-vertebral fractures, and 24 (1.3%) and 20 (1.0%), respectively, had a hip fracture. The proportion reporting at least one fall was 44% in vitamin D-treated and 43% in control residents. The differences between the vitamin D and control groups were not statistically significant. The incidence of all non-vertebral fractures in the care homes (3.2% per year) and of hip fractures (1.1% per year) was low, similar to rates in elderly people in sheltered accommodation, and the pre-treatment serum 25-hydroxy vitamin D concentration was high [median 47 nmol/l, measured in a 1% (n = 18) sample].
Conclusions
We found no evidence that vitamin D prevents fractures or falls in elderly people in care home accommodation.
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