Effects of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer--a double blind randomised controlled trial
Norman K, Stübler D, Baier P, Schütz T, Ocran K, Holm E, Lochs H, Pirlich M
Clinical nutrition (Edinburgh, Scotland) · 39 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-05-19 · Clin Nutr · vol. 25 · número 4 · págs. 596–605
- Editorial
- Elsevier BV
- Citado
- 50 citas · más que el 71% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Clinical Nutrition and Gastroenterology
- Palabras clave
- creatine supplementation, colorectal cancer, chemotherapy, nutritional status, muscle function, quality of life, body composition, phase angle, body cell mass, muscle strength, bioelectrical impedance analysis
- MeSH
- muscle, skeletal, humans, colorectal neoplasms, creatine, antineoplastic agents, hand strength, administration, oral, double-blind method, body composition, nutritional status, electric impedance, quality of life, dietary supplements, aged, middle aged, female, male, surveys and questionnaires
8 autores
- Kristina Norman🇩🇪Stiftung Charité; Charité - Universitätsmedizin Berlin
- Dominik Stübler🇩🇪Stiftung Charité; Charité - Universitätsmedizin Berlin
- Peter Baier🇩🇪Stiftung Charité; Charité - Universitätsmedizin Berlin
- T. Schütz🇩🇪Stiftung Charité; Charité - Universitätsmedizin Berlin
- KENNETH W. OCRAN🇩🇪Stiftung Charité; Charité - Universitätsmedizin Berlin
- Eggert Holm🇩🇪University Medical Centre Mannheim
- Herbert H. Lochs🇩🇪Stiftung Charité; Charité - Universitätsmedizin Berlin
- Matthias Pirlich🇩🇪 · autor de correspondenciaStiftung Charité; Charité - Universitätsmedizin Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aim
Nutritional status frequently deteriorates during chemotherapy in cancer. This is associated with a poor outcome. Since creatine supplementation has shown promising results in various diseases, we investigated the effects of creatine on nutritional status in patients with colorectal cancer undergoing chemotherapy.
Methods
Thirty patients with colorectal cancer undergoing chemotherapy were randomised to receive either creatine (n=16) or placebo (n=15) for 8 weeks. Body composition was determined with bioelectrical impedance analysis; muscle function by hand grip, hip flexion and knee extension strength and quality of life (QoL) was assessed by the QLQ30 questionnaire.
Results
Neither muscle function, body cell mass (BCM) nor QoL improved, but phase angle, a marker of BCM and cell integrity, increased significantly in the intervention patients (5.3+/-0.3 degrees to 5.4+/-0.2 degrees , P=0.030). Evaluating patients with different chemotherapy regimens, however, only intervention patients undergoing less aggressive chemotherapy were shown to benefit, increasing phase angle (5.11+/-0.22 degrees to 5.51+/-0.30 degrees , P=0.043) as well as BCM (27.22+/-2.85 to 29.60+/-3.54kg, P=0.043).
Conclusion
Creatine failed to improve muscle mass or function and QoL in colorectal cancer patients but improved bioimpedance parameters that are predictive of poor outcome. Creatine might therefore be useful in patients with milder chemotherapy in order to maintain or increase BCM whereas patients undergoing aggressive chemotherapy however are not likely to benefit.
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