Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers
Drapeau C, Hamel-Hébert I, Robillard R, Selmaoui B, Filipini D, Carrier J
Journal of sleep research · 79 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-05-16 · J Sleep Res · vol. 15 · número 2 · págs. 133–141
- Editorial
- Wiley
- Citado
- 115 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and related disorders · Sleep and Work-Related Fatigue
- Palabras clave
- caffeine, aging, sleep latency, sleep efficiency, sleep duration, stage 2 sleep, delta band, beta band, alpha frequency, prefrontal cortex, parietal cortex, homeostatic sleep drive, young and middle-aged adults
- MeSH
- frontal lobe, prefrontal cortex, parietal lobe, humans, caffeine, electroencephalography, drug administration schedule, cross-over studies, double-blind method, habits, sleep, sleep stages, circadian rhythm, aging, beverages, coffee, adult, aged, middle aged, female, male, sleep wake disorders
6 autores
- Caroline Drapeau🇨🇦Hôpital du Sacré-Cœur de Montréal; Université de Montréal
- Isabelle Hamel-Hébert🇨🇦Hôpital du Sacré-Cœur de Montréal; Université de Montréal
- Rébecca Robillard🇨🇦Hôpital du Sacré-Cœur de Montréal; Université de Montréal
- Brahim Selmaoui🇨🇦Hôpital du Sacré-Cœur de Montréal
- Daniel Filipini🇨🇦Hôpital du Sacré-Cœur de Montréal
- Julie Carrier🇨🇦 · autor de correspondenciaHôpital du Sacré-Cœur de Montréal; Université de Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study was to evaluate the effects of a 200-mg administration of caffeine on polysomnographic sleep variables and quantitative sleep electroencephalography (EEG) in 12 young (20-30 years) and 12 middle-aged (40-60 years) moderate caffeine consumers (one to three cups of coffee per day). All subjects were submitted to both a caffeine (200 mg) and placebo (lactose) condition in a double-blind cross-over design. The conditions were separated by 1 week. Compared with the placebo condition, the evening ingestion of caffeine lengthened sleep latency, reduced sleep efficiency, and decreased sleep duration and amount of stage 2 sleep in both age groups. Caffeine also reduced spectral power in delta frequencies in frontal, central and parietal brain areas, but not in prefrontal (PF) and occipital regions. Moreover, caffeine increased spectral power in beta frequencies in frontal and central brain areas in both age groups. A suppression of spectral power in the PF area in low delta frequencies (0.5-1.00 Hz) and a rise in spectral power in the parietal region in high alpha (10.00-12.00 Hz) and beta frequencies (17.00-21.00, 23.00-25.00, 27.00-29.00 Hz) occurred solely in middle-aged subjects. No such changes were noticeable in young subjects. Generally, caffeine produced similar effects in young and middle-aged subjects. Only a few frequency bins showed more effects of caffeine in middle-aged subjects compared with young subjects. Furthermore, sleep EEG results do not entirely support the hypothesis that caffeine fully mimics the effects of a reduction of homeostatic sleep propensity when following a normal sleep-wake cycle.
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