Photobiomodulation of pain and inflammation in microcrystalline arthropathies: experimental and clinical results
Soriano F, Campana V, Moya M, Gavotto A, Simes J, Soriano M, Soriano R, Spitale L, Palma J
Photomedicine and laser surgery · 33 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidad Nacional de Córdoba
- Universidad u hospital
- Universidad de Córdoba
- Universidad u hospital
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires
Según 3 financiadores declarados.
Publicación
- Publicado
- 2006-04-01 · Photomed Laser Surg · vol. 24 · número 2 · págs. 140–150
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 58 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Gout, Hyperuricemia, Uric Acid · Tendon Structure and Treatment
- Palabras clave
- low-level laser therapy, microcrystalline arthropathy, gout, calcium pyrophosphate deposition disease, hydroxyapatite deposition disease, analgesia, inflammation, diclofenac, prostaglandin E2, TNF-α, fibrinogen, rat model
- MeSH
- animals, humans, rats, arthralgia, arthritis, experimental, gout, durapatite, calcium pyrophosphate, diclofenac, uric acid, dinoprostone, tumor necrosis factor-alpha, fibrinogen, middle aged, female, laser therapy, biomarkers
9 autores
- Fernando Soriano
- Vilma Campana🇦🇷Universidad Nacional de Córdoba
- Maikro Osvaldo Chávez Moya🇦🇷Universidad Nacional de Córdoba
- Antonio Gavotto🇦🇷Universidad Nacional de Córdoba
- Juan Carlos Simes🇦🇷Universidad Nacional de Córdoba
- M. Soriano
- R. Soriano
- Luis Santos Spitale🇦🇷Universidad Nacional de Córdoba
- J. A. Palma🇦🇷Universidad Nacional de Córdoba
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This article presents the results of laser therapy in crystal (hydroxyapatite, calcium pyrophosphate, and urates) deposition-induced arthritis in rats and the clinical applications in humans.
Background data
Microcrystalline arthropathies are prevalent among geriatric patients, who are more vulnerable to the side effects of drugs. The effectiveness of laser therapy for pain relief, free of side effects, has been reported in painful conditions.
Methods
Two milligrams of each of the above-mentioned crystals was injected in both joints of the back limbs in three groups of rats; these groups were then treated with laser irradiation. Three other groups received no treatment after the injections. We determined the plasmatic levels of inflammatory markers (fibrinogen, prostaglandin E2, and TNF(alpha)), tissues (prostaglandin E(2)) and conducted anatomopathological studies. Twenty-five patients with acute gout arthritis were randomized into two groups and treated over 5 days: group A, diclofenac 75 mg orally, twice a day; and group B, laser irradiation once a day. Forty-nine patients with knee chronic pyrophosphate arthropathy were randomized into two groups and treated over 21 days; group A, diclofenac 50 mg orally, twice a day; and group B, laser irradiation once a day. Thirty patients with shoulder chronic hydroxyapatite arthropathy were randomized into two groups and treated over 21 days; group A, diclofenac 50 mg orally, twice a day; and group B, laser irradiation once a day.
Results
Fibrinogen, prostaglandin E(2), and TNF(alpha) concentrations in the rats injected with crystals and treated with laser decreased significantly as compared with the groups injected with crystals without treatment. Both laser therapy and diclofenac achieved rapid pain relief in patients with acute gouty arthritis without significant differences in efficacy. Laser therapy was more effective than diclofenac in patients with chronic pyrophosphate arthropathy and in patients with chronic apatite deposition disease.
Conclusion
Laser therapy represents an effective treatment in the therapeutic arsenal of microcrystalline arthropathies.
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