A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention
Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 133 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Helsingin Yliopisto
Según 1 financiador declarado.
Publicación
- Publicado
- 2006-06-01 · J Bone Miner Res · vol. 21 · número 6 · págs. 836–844
- Editorial
- Oxford University Press
- Citado
- 230 citas · más que el 98% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- vitamin D supplementation, vitamin D3, dose-response relationship, adolescent girls, lumbar spine, 25-hydroxyvitamin D, urinary pyridinoline, urinary deoxypyridinoline, bone resorption markers, osteocalcin, parathyroid hormone, calcium intake, osteoporosis prevention
- MeSH
- femur, lumbar vertebrae, humans, phosphates, calcium, cholecalciferol, calcifediol, radiography, double-blind method, calcification, physiologic, osteogenesis, dose-response relationship, drug, dietary supplements, child, finland, female, biomarkers
9 autores
- Heli T. Viljakainen🇫🇮University of Helsinki
- Anna-Mari Natri🇫🇮University of Helsinki
- Merja U. M. Kärkkäinen🇫🇮University of Helsinki
- Minna M. Huttunen🇫🇮University of Helsinki
- Anette Palssa🇫🇮University of Helsinki
- Jette Jakobsen
- Kevin D. Cashman
- Christian Mølgaard
- Christel J. E. Lamberg-Allardt🇫🇮 · autor de correspondenciaUniversity of Helsinki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.
Introduction
Adequate vitamin D intake protects the elderly against osteoporosis, but there exists no indisputable evidence that vitamin D supplementation would benefit bone mineral augmentation. The aim of this 1-year study was to determine in a randomized double-blinded trial the effect of 5 and 10 microg vitamin D3 supplementation on bone mineral augmentation in adolescent girls with adequate dietary calcium intake.
Materials and methods
Altogether, 228 girls (mean age, 11.4 +/- 0.4 years) participated. Their BMC was measured by DXA from the femur and lumbar spine. Serum 25-hydroxyvitamin D [S-25(OH)D], intact PTH (S-iPTH), osteocalcin (S-OC), and urinary pyridinoline (U-Pyr) and deoxypyridinoline (U-Dpyr) were measured. Statistical analysis was performed both with the intention-to-treat (IT) and compliance-based (CB) method.
Results
In the CB analysis, vitamin D supplementation increased femoral BMC augmentation by 14.3% with 5 microg and by 17.2% with 10 microg compared with the placebo group (ANCOVA, p = 0.012). A dose-response effect was observed in the vertebrae (ANCOVA, p = 0.039), although only with the highest dose. The mean concentration of S-25(OH)D increased (p < 0.001) in the 5-microg group by 5.7 +/- 15.7 nM and in the 10-microg group by 12.4 +/- 13.7 nM, whereas it decreased by 6.7 +/- 11.3 nM in the placebo group. Supplementation had no effect on S-iPTH or S-OC, but it decreased U-DPyr (p = 0.042).
Conclusions
Bone mineral augmentation in the femur was 14.3% and 17.2% higher in the groups receiving 5 and 10 microg of vitamin D, respectively, compared with the placebo group, but only 10 mug increased lumbar spine BMC augmentation significantly. Vitamin D supplementation decreased the concentration of bone resorption markers, but had no impact on bone formation markers, thus explaining increased bone mineral augmentation. However, the positive effects were noted with the CB method but not with IT.
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