Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial
Gontijo-Amaral C, Ribeiro MA, Gontijo LS, Condino-Neto A, Ribeiro JD
European journal of clinical nutrition · 38 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-06-21 · Eur J Clin Nutr · vol. 61 · número 1 · págs. 54–60
- Editorial
- Springer Nature
- Citado
- 65 citas · más que el 87% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Asthma and respiratory diseases · Magnesium in Health and Disease · Occupational exposure and asthma
- Palabras clave
- oral magnesium supplementation, childhood asthma, moderate persistent asthma, airway hyperresponsiveness, methacholine challenge, lung function, asthma exacerbations, salbutamol use, fluticasone, symptom management
- MeSH
- humans, asthma, magnesium, albuterol, androstadienes, bronchodilator agents, vital capacity, forced expiratory flow rates, forced expiratory volume, treatment outcome, drug therapy, combination, double-blind method, dietary supplements, adolescent, adult, child, brazil, female, male, fluticasone
5 autores
- C Gontijo-Amaral🇧🇷 · autor de correspondenciaUniversidade Estadual de Campinas (UNICAMP)
- Maria Ângela Gonçalves de Oliveira Ribeiro🇧🇷Universidade Estadual de Campinas (UNICAMP)
- L S C Gontijo🇧🇷Universidade Estadual de Campinas (UNICAMP)
- Antônio Condino‐Neto🇧🇷Universidade de São Paulo; Universidade Estadual de Campinas (UNICAMP)
- José Dirceu Ribeiro🇧🇷Universidade Estadual de Campinas (UNICAMP)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the long-term effect of oral magnesium supplementation on clinical symptoms, bronchial reactivity, lung function and allergen-induced skin responses in children and adolescents with moderate persistent asthma.
Design
A double-blind randomized parallel placebo-controlled study.
Setting and subjects
The patients were recruited from the Pediatric Outpatient Clinic, Division of Pulmonology, Allergy and Immunology, and followed at the Center for Investigation in Pediatrics at State University of Campinas Hospital, Brazil. Thirty-seven out of 72 patients met the study criteria. There were no dropouts.
Intervention
The 37 patients (aged 7-19 years, 19 males) were randomized in two groups: magnesium (n=18, 300 mg/day) and placebo (n=19), during 2 months. Both patient groups received inhaled fluticasone (250 microg twice a day) and salbutamol as needed. The primary outcome was bronchial reactivity evaluated with methacholine challenge test (PC20).
Results
After a follow-up of 2 months, the methacholine PC20 for testing bronchial reactivity has augmented significantly in the magnesium group only. The skin responses to recognized antigens have also decreased in patients treated with magnesium. The forced vital capacity (FVC), the forced expiratory volume at first second (FEV1), the forced expiratory flow at 25-75 and the FEV1/FVC ratio were similar in both groups. The magnesium group presented fewer asthma exacerbations and used less salbutamol compared to the placebo group.
Conclusions
Oral magnesium supplementation helped to reduce bronchial reactivity to methacholine, to diminish their allergen-induced skin responses and to provide better symptom control in pediatric patients with moderate persistent asthma treated with inhaled fluticasone.
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