The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation
Killgore WD, McBride SA, Killgore DB, Balkin TJ
Sleep · 41 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Defense
Según 1 financiador declarado.
Publicación
- Publicado
- 2006-06-01 · Sleep · vol. 29 · número 6 · págs. 841–847
- Editorial
- Oxford University Press
- Citado
- 71 citas · más que el 97% de estudios similares · 8.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Coffee research and impacts
- Palabras clave
- sleep deprivation, humor appreciation, caffeine, d-amphetamine, modafinil, stimulant medication, executive function, prefrontal cortex, subjective sleepiness, cartoons, verbal humor
- MeSH
- humans, psychomotor agitation, sleep deprivation, disorders of excessive somnolence, dextroamphetamine, benzhydryl compounds, caffeine, central nervous system stimulants, cognition, psychological tests, adolescent, adult, female, male, wit and humor as topic, modafinil
4 autores
- William D. S. Killgore🇺🇸 · autor de correspondenciaWalter Reed Army Institute of Research
- Sharon McBride🇺🇸Walter Reed Army Institute of Research
- Desiree B. Killgore🇺🇸Walter Reed Army Institute of Research
- Thomas J. Balkin🇺🇸Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Study objectives
Sleep loss consistently impairs performance on measures of alertness, vigilance, and response speed, but its effects on higher-order executive functions are not well delineated. Similarly, whereas deficits in arousal and vigilance can be temporarily countered by the use of several different stimulant medications, it is not clear how these compounds affect complex cognitive processes in sleep-deprived individuals.
Design
We evaluated the effects of double-blind administration of 3 stimulant medications or placebo on the ability to appreciate humor in visual (cartoons) or verbal (headlines) stimuli presented on a computer screen following 49.5 hours of sleep deprivation.
Setting
In-residence sleep-laboratory facility at the Walter Reed Army Institute of Research.
Participants
Fifty-four healthy adults (29 men, 24 women), ranging in age from 18 to 36 years.
Interventions
Each participant was randomly assigned to 1 of 3 stimulant medication groups, including caffeine, 600 mg, n = 12; modafinil, 400 mg, n = 11; dextroamphetamine, 20 mg, n = 16; or placebo, n = 14.
Measurements and results
Humor appreciation for cartoon stimuli was enhanced by modafinil relative to both placebo and caffeine, but there was no effect of any stimulant medication on the appreciation of verbal humor during sleep loss. In contrast, all 3 stimulants improved psychomotor response speed, whereas only caffeine and dextroamphetamine improved ratings of subjective sleepiness.
Conclusions
Findings suggest that, despite similar alerting and vigilance-promoting effects, these 3 compounds have significantly different effects on those highly complex cognitive abilities mediated by the pre-frontal cortex.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.