Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension
Wu G, Tian H, Han K, Xi Y, Yao Y, Ma A
Clinical and experimental hypertension (New York, N.Y. : 1993) · 11 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
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Publicación
- Publicado
- 2006-01-01 · Clin Exp Hypertens · vol. 28 · número 5 · págs. 489–497
- Editorial
- Informa
- Citado
- 25 citas · más que el 78% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Blood Pressure and Hypertension Studies · Magnesium in Health and Disease
- Palabras clave
- hypertension, potassium supplementation, magnesium supplementation, arterial compliance, blood pressure reduction, lacidipine, systemic vascular resistance, antihypertensive therapy, dietary mineral supplementation, cardiovascular risk factors, arterial stiffness, cardiovascular risk stratification, cardiovascular risk prevention
- MeSH
- arteries, humans, hypertension, magnesium, potassium, dietary, dihydropyridines, antihypertensive agents, treatment outcome, multivariate analysis, case-control studies, follow-up studies, blood pressure, vascular resistance, time factors, dietary supplements, adult, aged, middle aged, female, male, biomarkers
6 autores
- Geru Wu🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an; Xi'an Jiaotong University
- Hongyan Tian🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an; Xi'an Jiaotong University
- Ke Han🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an; Xi'an Jiaotong University
- Yutao T Xi🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an; Xi'an Jiaotong University
- Yan Yao🇨🇳First Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an; Xi'an Jiaotong University
- Aiqun Ma🇨🇳 · autor de correspondenciaFirst Affiliated Hospital of Xi'an Jiaotong University; First Hospital of Xi'an; Xi'an Jiaotong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
It has been postulated that the loss of arterial compliance may precede cardiovascular diseases, and that arterial compliance is an important parameter to consider when evaluating arterial diseases such as essential hypertension (EH) and the effects of antihypertensive treatment. In all, 133 EH patients and 147 healthy subjects were enrolled in this study. Large arterial compliance (C1) and small arterial compliance (C2) were measured by the CVProfilor DO-2020 CardioVascular Profiling System. Thirty-five patients randomly received magnesium potassium supplementation (magnesium, 70.8 mg/d; potassium, 217.2 mg/d) for four weeks, and 32 patients received lacidipin (4 mg/d) as a control. Before and after the four weeks, blood pressure, C1, and C2 were measured. It was found that arterial compliance was significantly lower in EH patients compared with healthy subjects (C1: 12.53 +/- 0.33 vs. 15.63 +/- 0.30 ml/mmHg x 10, p < 0.01;C2: 3.79 +/- 0.17 vs. 5.69 +/- 0.25 ml/mmHg x 100, p < 0.01). On lacidipine, systolic and diastolic BP decreased 13.27 +/- 1.76 mm Hg and 6.33 +/- 1.55 mm Hg, and C1 and C2 compliance values increased 25.05% +/- 4.49% and 34.50% +/- 7.40%, respectively. On K+ and Mg2+ supplementation, systolic and diastolic BP decreased 7.83 +/- 1.87 mm Hg and 3.67 +/- 1.03 mm Hg, and C1 and C2 compliance values increased 12.44% +/- 4.43% and 45.25% +/- 6.67%, respectively. Decreases in systemic vascular resistance (mean arterial pressure divided by cardiac output) by 11.9% and 16.6 % (p < 0.01) were seen between the drug-induced changes, respectively. Both large arterial compliance and small arterial compliance were decreased in essential hypertension patients. In essential hypertension patients, magnesium and potassium supplementation could improve small arterial compliance, while lacidipine improved large arterial compliance significantly.
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