Oral magnesium therapy, exercise heart rate, exercise tolerance, and myocardial function in coronary artery disease patients
Pokan R, Hofmann P, von Duvillard SP, Smekal G, Wonisch M, Lettner K, Schmid P, Shechter M, Silver B, Bachl N
British journal of sports medicine · 28 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-07-06 · Br J Sports Med · vol. 40 · número 9 · págs. 773–778
- Editorial
- BMJ
- Citado
- 50 citas · más que el 79% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular and exercise physiology · Heart rate and cardiovascular health
- Palabras clave
- oral magnesium supplementation, coronary artery disease, heart rate response to exercise, exercise tolerance, VO2max, left ventricular ejection fraction, myocardial function, intracellular magnesium, stable angina, endothelial function, myocardial ischemia, exercise-induced chest pain, myocardial stunning, myocardial stunning recovery, myocardial stunning duration, myocardial stunning recovery time
- MeSH
- endothelium, vascular, humans, magnesium, exercise test, exercise, administration, oral, prospective studies, double-blind method, oxygen consumption, heart rate, ventricular function, left, exercise tolerance, dietary supplements, aged, middle aged, male, coronary artery disease
10 autores
- Rochus Pokan🇦🇹University of Vienna
- Peter Hofmann🇦🇹University of Graz
- SERGE PETELIN von DUVILLARD🇺🇸 · autor de correspondenciaEast Texas A&M University
- Gerhard Smekal🇦🇹University of Vienna
- Manfred Wonisch🇦🇹University of Graz
- Karin Lettner🇦🇹University of Vienna
- Peter Schmid
- Michael Shechter🇮🇱Tel Aviv University; Sheba Medical Center
- B Silver
- Norbert Bachl🇦🇹University of Vienna
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous studies have demonstrated that in patients with coronary artery disease (CAD) upward deflection of the heart rate (HR) performance curve can be observed and that this upward deflection and the degree of the deflection are correlated with a diminished stress dependent left ventricular function. Magnesium supplementation improves endothelial function, exercise tolerance, and exercise induced chest pain in patients with CAD.
Purpose
We studied the effects of oral magnesium therapy on exercise dependent HR as related to exercise tolerance and resting myocardial function in patients with CAD.
Methods
In a double blind controlled trial, 53 male patients with stable CAD were randomised to either oral magnesium 15 mmol twice daily (n = 28, age 61+/-9 years, height 171+/-7 cm, body weight 79+/-10 kg, previous myocardial infarction, n = 7) or placebo (n = 25, age 58+/-10 years, height 172+/-6 cm, body weight 79+/-10 kg, previous myocardial infarction, n = 6) for 6 months. Maximal oxygen uptake (VO2max), the degree and direction of the deflection of the HR performance curve described as factor k<0 (upward deflection), and the left ventricular ejection fraction (LVEF) were the outcomes measured.
Results
Magnesium therapy for 6 months significantly increased intracellular magnesium levels (32.7+/-2.5 v 35.6+/-2.1 mEq/l, p<0.001) compared to placebo (33.1+/-3.1.9 v 33.8+/-2.0 mEq/l, NS), VO2max (28.3+/-6.2 v 30.6+/-7.1 ml/kg/min, p<0.001; 29.3+/-5.4 v 29.6+/-5.2 ml/kg/min, NS), factor k (-0.298+/-0.242 v -0.208+/-0.260, p<0.05; -0.269+/-0.336 v -0.272+/-0.335, NS), and LVEF (58+/-11 v 67+/-10%, p<0.001; 55+/-11 v 54+/-12%, NS).
Conclusion
The present study supports the intake of oral magnesium and its favourable effects on exercise tolerance and left ventricular function during rest and exercise in stable CAD patients.
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